Optical Imaging of Dynamic Collagen Processes in Health and Disease
Collagen is a major structural component of nearly every tissue in the human body, whose hierarchical organization imparts specific mechanical properties and defines overall tissue function. Collagenous soft tissues are dynamic structures that are in a constant state of remodeling but are also prone...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Mechanical Engineering |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmech.2022.855271/full |
| _version_ | 1818392757796864000 |
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| author | Leanne E. Iannucci Charles S. Dranoff Michael A. David Spencer P. Lake Spencer P. Lake Spencer P. Lake |
| author_facet | Leanne E. Iannucci Charles S. Dranoff Michael A. David Spencer P. Lake Spencer P. Lake Spencer P. Lake |
| author_sort | Leanne E. Iannucci |
| collection | DOAJ |
| description | Collagen is a major structural component of nearly every tissue in the human body, whose hierarchical organization imparts specific mechanical properties and defines overall tissue function. Collagenous soft tissues are dynamic structures that are in a constant state of remodeling but are also prone to damage and pathology. Optical techniques are uniquely suited for imaging collagen in these dynamic situations as they allow for non-invasive monitoring with relatively high spatiotemporal resolution. This review presents an overview of common collagen dynamic processes associated with human health and disease and optical imaging approaches that are uniquely suited for monitoring, sensing, and diagnosing these changes. This review aims to 1) provide researchers with an understanding of the underlying optical properties of collagen that can be leveraged for extracellular matrix visualization and 2) present emerging opportunities for machine learning approaches to drive multiscale and multimodality solutions. |
| first_indexed | 2024-12-14T05:34:30Z |
| format | Article |
| id | doaj.art-c97bd2984c0a4f9e9cc887daf1ea1167 |
| institution | Directory Open Access Journal |
| issn | 2297-3079 |
| language | English |
| last_indexed | 2024-12-14T05:34:30Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Mechanical Engineering |
| spelling | doaj.art-c97bd2984c0a4f9e9cc887daf1ea11672022-12-21T23:15:14ZengFrontiers Media S.A.Frontiers in Mechanical Engineering2297-30792022-03-01810.3389/fmech.2022.855271855271Optical Imaging of Dynamic Collagen Processes in Health and DiseaseLeanne E. Iannucci0Charles S. Dranoff1Michael A. David2Spencer P. Lake3Spencer P. Lake4Spencer P. Lake5Department of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Mechanical Engineering and Materials Science, McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Mechanical Engineering and Materials Science, McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Orthopaedic Surgery, School of Medicine, Washington University in St. Louis, St. Louis, MO, United StatesCollagen is a major structural component of nearly every tissue in the human body, whose hierarchical organization imparts specific mechanical properties and defines overall tissue function. Collagenous soft tissues are dynamic structures that are in a constant state of remodeling but are also prone to damage and pathology. Optical techniques are uniquely suited for imaging collagen in these dynamic situations as they allow for non-invasive monitoring with relatively high spatiotemporal resolution. This review presents an overview of common collagen dynamic processes associated with human health and disease and optical imaging approaches that are uniquely suited for monitoring, sensing, and diagnosing these changes. This review aims to 1) provide researchers with an understanding of the underlying optical properties of collagen that can be leveraged for extracellular matrix visualization and 2) present emerging opportunities for machine learning approaches to drive multiscale and multimodality solutions.https://www.frontiersin.org/articles/10.3389/fmech.2022.855271/fullextracellular matrixdamageremodelinghealingbiophotonicsbiomedical optics |
| spellingShingle | Leanne E. Iannucci Charles S. Dranoff Michael A. David Spencer P. Lake Spencer P. Lake Spencer P. Lake Optical Imaging of Dynamic Collagen Processes in Health and Disease Frontiers in Mechanical Engineering extracellular matrix damage remodeling healing biophotonics biomedical optics |
| title | Optical Imaging of Dynamic Collagen Processes in Health and Disease |
| title_full | Optical Imaging of Dynamic Collagen Processes in Health and Disease |
| title_fullStr | Optical Imaging of Dynamic Collagen Processes in Health and Disease |
| title_full_unstemmed | Optical Imaging of Dynamic Collagen Processes in Health and Disease |
| title_short | Optical Imaging of Dynamic Collagen Processes in Health and Disease |
| title_sort | optical imaging of dynamic collagen processes in health and disease |
| topic | extracellular matrix damage remodeling healing biophotonics biomedical optics |
| url | https://www.frontiersin.org/articles/10.3389/fmech.2022.855271/full |
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