Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy

Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy

Celiac disease is characterized by intolerance to gluten, a cereal protein. Here, the authors show that neprosin, a glutamate peptidase from the pitcher plant, efficiently cleaves gluten components under physiological conditions in vitro and in the gut of mice.

Bibliographic Details
Main Authors: Laura del Amo-Maestro, Soraia R. Mendes, Arturo Rodríguez-Banqueri, Laura Garzon-Flores, Marina Girbal, María José Rodríguez-Lagunas, Tibisay Guevara, Àngels Franch, Francisco J. Pérez-Cano, Ulrich Eckhard, F. Xavier Gomis-Rüth
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32215-1

Internet

https://doi.org/10.1038/s41467-022-32215-1

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