Seeking Overlapping Neuroanatomical Alterations between Dyslexia and Attention-Deficit/Hyperactivity Disorder: A Meta-Analytic Replication Study
The present work is a replication article based on the paper “Are there shared neural correlates between dyslexia and ADHD? A meta-analysis of voxel-based morphometry studies” by McGrath and Stoodley (2019). In the original research, the authors used activation likelihood estimation (ALE), a techniq...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/10/1367 |
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| author | Donato Liloia Annachiara Crocetta Franco Cauda Sergio Duca Tommaso Costa Jordi Manuello |
| author_facet | Donato Liloia Annachiara Crocetta Franco Cauda Sergio Duca Tommaso Costa Jordi Manuello |
| author_sort | Donato Liloia |
| collection | DOAJ |
| description | The present work is a replication article based on the paper “Are there shared neural correlates between dyslexia and ADHD? A meta-analysis of voxel-based morphometry studies” by McGrath and Stoodley (2019). In the original research, the authors used activation likelihood estimation (ALE), a technique to perform coordinate-based meta-analysis (CBMA), to investigate the existence of brain regions undergoing gray matter alteration in association with both attention-deficit/hyper-activity disorder (ADHD) and dyslexia. Here, the same voxel-based morphometry dataset was analyzed, while using the permutation-subject images version of signed differential mapping (PSI-SDM) in place of ALE. Overall, the replication converged with the original paper in showing a limited overlap between the two conditions. In particular, no significant effect was found for dyslexia, therefore precluding any form of comparison between the two disorders. The possible influences of biological sex, age, and medication status were also ruled out. Our findings are in line with literature about gray matter alteration associated with ADHD and dyslexia, often showing conflicting results. Therefore, although neuropsychological and clinical evidence suggest some convergence between ADHD and dyslexia, more future research is sorely needed to reach a consensus on the neuroimaging domain in terms of patterns of gray matter alteration. |
| first_indexed | 2024-03-09T20:35:21Z |
| format | Article |
| id | doaj.art-c97c157ab8ee4fa1a2fb84796ce850ec |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T20:35:21Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-c97c157ab8ee4fa1a2fb84796ce850ec2023-11-23T23:14:16ZengMDPI AGBrain Sciences2076-34252022-10-011210136710.3390/brainsci12101367Seeking Overlapping Neuroanatomical Alterations between Dyslexia and Attention-Deficit/Hyperactivity Disorder: A Meta-Analytic Replication StudyDonato Liloia0Annachiara Crocetta1Franco Cauda2Sergio Duca3Tommaso Costa4Jordi Manuello5GCS fMRI Koelliker Group, Koelliker Hospital and University of Turin, 10124 Turin, ItalyFOCUS Laboratory, Department of Psychology, University of Turin, 10124 Turin, ItalyGCS fMRI Koelliker Group, Koelliker Hospital and University of Turin, 10124 Turin, ItalyGCS fMRI Koelliker Group, Koelliker Hospital and University of Turin, 10124 Turin, ItalyGCS fMRI Koelliker Group, Koelliker Hospital and University of Turin, 10124 Turin, ItalyGCS fMRI Koelliker Group, Koelliker Hospital and University of Turin, 10124 Turin, ItalyThe present work is a replication article based on the paper “Are there shared neural correlates between dyslexia and ADHD? A meta-analysis of voxel-based morphometry studies” by McGrath and Stoodley (2019). In the original research, the authors used activation likelihood estimation (ALE), a technique to perform coordinate-based meta-analysis (CBMA), to investigate the existence of brain regions undergoing gray matter alteration in association with both attention-deficit/hyper-activity disorder (ADHD) and dyslexia. Here, the same voxel-based morphometry dataset was analyzed, while using the permutation-subject images version of signed differential mapping (PSI-SDM) in place of ALE. Overall, the replication converged with the original paper in showing a limited overlap between the two conditions. In particular, no significant effect was found for dyslexia, therefore precluding any form of comparison between the two disorders. The possible influences of biological sex, age, and medication status were also ruled out. Our findings are in line with literature about gray matter alteration associated with ADHD and dyslexia, often showing conflicting results. Therefore, although neuropsychological and clinical evidence suggest some convergence between ADHD and dyslexia, more future research is sorely needed to reach a consensus on the neuroimaging domain in terms of patterns of gray matter alteration.https://www.mdpi.com/2076-3425/12/10/1367coordinate-based meta-analysisvoxel-based morphometryADHDdyslexiaALEseed-based d mapping |
| spellingShingle | Donato Liloia Annachiara Crocetta Franco Cauda Sergio Duca Tommaso Costa Jordi Manuello Seeking Overlapping Neuroanatomical Alterations between Dyslexia and Attention-Deficit/Hyperactivity Disorder: A Meta-Analytic Replication Study Brain Sciences coordinate-based meta-analysis voxel-based morphometry ADHD dyslexia ALE seed-based d mapping |
| title | Seeking Overlapping Neuroanatomical Alterations between Dyslexia and Attention-Deficit/Hyperactivity Disorder: A Meta-Analytic Replication Study |
| title_full | Seeking Overlapping Neuroanatomical Alterations between Dyslexia and Attention-Deficit/Hyperactivity Disorder: A Meta-Analytic Replication Study |
| title_fullStr | Seeking Overlapping Neuroanatomical Alterations between Dyslexia and Attention-Deficit/Hyperactivity Disorder: A Meta-Analytic Replication Study |
| title_full_unstemmed | Seeking Overlapping Neuroanatomical Alterations between Dyslexia and Attention-Deficit/Hyperactivity Disorder: A Meta-Analytic Replication Study |
| title_short | Seeking Overlapping Neuroanatomical Alterations between Dyslexia and Attention-Deficit/Hyperactivity Disorder: A Meta-Analytic Replication Study |
| title_sort | seeking overlapping neuroanatomical alterations between dyslexia and attention deficit hyperactivity disorder a meta analytic replication study |
| topic | coordinate-based meta-analysis voxel-based morphometry ADHD dyslexia ALE seed-based d mapping |
| url | https://www.mdpi.com/2076-3425/12/10/1367 |
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