Glycated albumin is a better indicator for glucose levels than glycated hemoglobin in patients with diabetes mellitus on insulin therapy
Background Diabetes mellitus (DM) is a metabolic disease with a large incidence in the world and constitutes a global health problem. By 2030 it is estimated that there will be around 439 million people suffering from DM. Diabetes mellitus is a metabolic disease caused by a lack or absence of the ho...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine Trisakti University
2020-03-01
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| Series: | Universa Medicina |
| Subjects: | |
| Online Access: | https://univmed.org/ejurnal/index.php/medicina/article/view/881 |
| _version_ | 1831543335622279168 |
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| author | Alvina Lesmana Pusparini Pusparini Meiyanti Meiyanti Lie T Merijanti |
| author_facet | Alvina Lesmana Pusparini Pusparini Meiyanti Meiyanti Lie T Merijanti |
| author_sort | Alvina Lesmana |
| collection | DOAJ |
| description | Background
Diabetes mellitus (DM) is a metabolic disease with a large incidence in the world and constitutes a global health problem. By 2030 it is estimated that there will be around 439 million people suffering from DM. Diabetes mellitus is a metabolic disease caused by a lack or absence of the hormone insulin. In type 2 DM pharmacotherapy can be given one of which is insulin. To monitor therapy, random blood glucose, glycated hemoglobin (HbA1c) and glycated albumin (GA) levels can be examined. The objective of this study was to determine the relationship of glycated albumin and glycated hemoglobin (HbA1c) with random blood glucose in insulin-treated diabetics.
Methods
A cross-sectional study was conducted involving 92 type 2 diabetic patients treated with insulin. The study used a questionnaire and blood samples. We measured the GA , HbA1C and random blood glucose levels. A multiple linear regression was used to analyze the data.
Results
Mean HbA1c was 9.21 ± 2.15%, mean glycated albumin was 24.4 ± 8.65%, and mean blood glucose was 229.47 ± 98.7 mg/dL. Multiple linear regression tests showed that HbA1c (B= 5,544; â=0.121; p=0.420) and GA (B=5.899; â=0.517; p=0.001) was signigicantly corelated with random blood gucose, respectively, indicating that glycated albumin is significantly related to and has the greatest influence on glucose level.
Conclusion
Glycated albumin is correlated with and has greater influence on glucose level than does HbA1c. Glycated albumin could be a better marker for glycemic control than glycated hemoglobin in diabetic patients treated with insulin. |
| first_indexed | 2024-12-17T00:49:28Z |
| format | Article |
| id | doaj.art-c97c6c0ab2ee41a19e9a0218e025f130 |
| institution | Directory Open Access Journal |
| issn | 1907-3062 2407-2230 |
| language | English |
| last_indexed | 2024-12-17T00:49:28Z |
| publishDate | 2020-03-01 |
| publisher | Faculty of Medicine Trisakti University |
| record_format | Article |
| series | Universa Medicina |
| spelling | doaj.art-c97c6c0ab2ee41a19e9a0218e025f1302022-12-21T22:09:48ZengFaculty of Medicine Trisakti UniversityUniversa Medicina1907-30622407-22302020-03-0139110.18051/UnivMed.2020.v39.27-33397Glycated albumin is a better indicator for glucose levels than glycated hemoglobin in patients with diabetes mellitus on insulin therapyAlvina Lesmana0Pusparini Pusparini1Meiyanti Meiyanti2Lie T Merijanti3Department of Clinical Pathology of Medicine Trisakti UniversityDepartment of Clinical Pathology of Medicine Trisakti UniversityDepartment of Pharmacology and Pharmacy Faculty of Medicine Trisakti UniversityDepartment of Occupational Medicine Faculty of Medicine Trisakti UniversityBackground Diabetes mellitus (DM) is a metabolic disease with a large incidence in the world and constitutes a global health problem. By 2030 it is estimated that there will be around 439 million people suffering from DM. Diabetes mellitus is a metabolic disease caused by a lack or absence of the hormone insulin. In type 2 DM pharmacotherapy can be given one of which is insulin. To monitor therapy, random blood glucose, glycated hemoglobin (HbA1c) and glycated albumin (GA) levels can be examined. The objective of this study was to determine the relationship of glycated albumin and glycated hemoglobin (HbA1c) with random blood glucose in insulin-treated diabetics. Methods A cross-sectional study was conducted involving 92 type 2 diabetic patients treated with insulin. The study used a questionnaire and blood samples. We measured the GA , HbA1C and random blood glucose levels. A multiple linear regression was used to analyze the data. Results Mean HbA1c was 9.21 ± 2.15%, mean glycated albumin was 24.4 ± 8.65%, and mean blood glucose was 229.47 ± 98.7 mg/dL. Multiple linear regression tests showed that HbA1c (B= 5,544; â=0.121; p=0.420) and GA (B=5.899; â=0.517; p=0.001) was signigicantly corelated with random blood gucose, respectively, indicating that glycated albumin is significantly related to and has the greatest influence on glucose level. Conclusion Glycated albumin is correlated with and has greater influence on glucose level than does HbA1c. Glycated albumin could be a better marker for glycemic control than glycated hemoglobin in diabetic patients treated with insulin.https://univmed.org/ejurnal/index.php/medicina/article/view/881HbA1cglycated albuminblood glucosediabetic type 2 patients |
| spellingShingle | Alvina Lesmana Pusparini Pusparini Meiyanti Meiyanti Lie T Merijanti Glycated albumin is a better indicator for glucose levels than glycated hemoglobin in patients with diabetes mellitus on insulin therapy Universa Medicina HbA1c glycated albumin blood glucose diabetic type 2 patients |
| title | Glycated albumin is a better indicator for glucose levels than glycated hemoglobin in patients with diabetes mellitus on insulin therapy |
| title_full | Glycated albumin is a better indicator for glucose levels than glycated hemoglobin in patients with diabetes mellitus on insulin therapy |
| title_fullStr | Glycated albumin is a better indicator for glucose levels than glycated hemoglobin in patients with diabetes mellitus on insulin therapy |
| title_full_unstemmed | Glycated albumin is a better indicator for glucose levels than glycated hemoglobin in patients with diabetes mellitus on insulin therapy |
| title_short | Glycated albumin is a better indicator for glucose levels than glycated hemoglobin in patients with diabetes mellitus on insulin therapy |
| title_sort | glycated albumin is a better indicator for glucose levels than glycated hemoglobin in patients with diabetes mellitus on insulin therapy |
| topic | HbA1c glycated albumin blood glucose diabetic type 2 patients |
| url | https://univmed.org/ejurnal/index.php/medicina/article/view/881 |
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