Prognostic Role of the Activated p-AKT Molecule in Various Hematologic Malignancies and Solid Tumors: A Meta-Analysis
Cancer is one of the main causes of human death worldwide. Recently, many studies have firmly established the causal relationship between oxidative stress and cancer initiation and progression. As a key protein in PI3K/Akt signaling pathway, p-AKT (phosphorylated Akt) participates in the process of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.588200/full |
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| author | Zhen Yao Guangyu Gao Jiawen Yang Yuming Long Zhenzhen Wang Wentao Hu Wentao Hu Yulong Liu Yulong Liu Yulong Liu |
| author_facet | Zhen Yao Guangyu Gao Jiawen Yang Yuming Long Zhenzhen Wang Wentao Hu Wentao Hu Yulong Liu Yulong Liu Yulong Liu |
| author_sort | Zhen Yao |
| collection | DOAJ |
| description | Cancer is one of the main causes of human death worldwide. Recently, many studies have firmly established the causal relationship between oxidative stress and cancer initiation and progression. As a key protein in PI3K/Akt signaling pathway, p-AKT (phosphorylated Akt) participates in the process of oxidative stress and plays a prognostic role in various hematologic tumors and solid tumors. We conducted a comprehensive search of the PubMed, Embase and Cochrane libraries to identify studies published in the past decade involving cancer patients expressing p-AKT that reported overall survival (OS) during follow-up. In this study, 6,128 patients in total were evaluated from 29 enrolled articles, and we concluded that overexpression of p-AKT was closely related to worse OS in cancer patients with a hazard ratio (HR) of 2.33 (95% CI: 1.67–4.00). Furthermore, we conducted a subgroup analysis, and the results indicated that overexpression of p-AKT was associated with worse OS in hematological tumor (HR: 1.64, 95% CI: 1.41–1.92), and solid tumor (HR: 2.44, 95% CI: 1.61–5.26). High expression of p-AKT is related to poor prognosis of various hematologic tumors and solid tumors. |
| first_indexed | 2024-12-20T03:25:52Z |
| format | Article |
| id | doaj.art-c97cb947e0444bb593e3ac9ceea94c9b |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-20T03:25:52Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c97cb947e0444bb593e3ac9ceea94c9b2022-12-21T19:55:05ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-12-011010.3389/fonc.2020.588200588200Prognostic Role of the Activated p-AKT Molecule in Various Hematologic Malignancies and Solid Tumors: A Meta-AnalysisZhen Yao0Guangyu Gao1Jiawen Yang2Yuming Long3Zhenzhen Wang4Wentao Hu5Wentao Hu6Yulong Liu7Yulong Liu8Yulong Liu9Department of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Ultrasound, Xingtang Hospital, Suzhou, ChinaDepartment of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou, ChinaCollaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou, ChinaDepartment of Nuclear Accident Medical Emergency, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou, ChinaCollaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou, ChinaCancer is one of the main causes of human death worldwide. Recently, many studies have firmly established the causal relationship between oxidative stress and cancer initiation and progression. As a key protein in PI3K/Akt signaling pathway, p-AKT (phosphorylated Akt) participates in the process of oxidative stress and plays a prognostic role in various hematologic tumors and solid tumors. We conducted a comprehensive search of the PubMed, Embase and Cochrane libraries to identify studies published in the past decade involving cancer patients expressing p-AKT that reported overall survival (OS) during follow-up. In this study, 6,128 patients in total were evaluated from 29 enrolled articles, and we concluded that overexpression of p-AKT was closely related to worse OS in cancer patients with a hazard ratio (HR) of 2.33 (95% CI: 1.67–4.00). Furthermore, we conducted a subgroup analysis, and the results indicated that overexpression of p-AKT was associated with worse OS in hematological tumor (HR: 1.64, 95% CI: 1.41–1.92), and solid tumor (HR: 2.44, 95% CI: 1.61–5.26). High expression of p-AKT is related to poor prognosis of various hematologic tumors and solid tumors.https://www.frontiersin.org/articles/10.3389/fonc.2020.588200/fullp-AKTtumormeta-analysisoxidative stressbiomarker |
| spellingShingle | Zhen Yao Guangyu Gao Jiawen Yang Yuming Long Zhenzhen Wang Wentao Hu Wentao Hu Yulong Liu Yulong Liu Yulong Liu Prognostic Role of the Activated p-AKT Molecule in Various Hematologic Malignancies and Solid Tumors: A Meta-Analysis Frontiers in Oncology p-AKT tumor meta-analysis oxidative stress biomarker |
| title | Prognostic Role of the Activated p-AKT Molecule in Various Hematologic Malignancies and Solid Tumors: A Meta-Analysis |
| title_full | Prognostic Role of the Activated p-AKT Molecule in Various Hematologic Malignancies and Solid Tumors: A Meta-Analysis |
| title_fullStr | Prognostic Role of the Activated p-AKT Molecule in Various Hematologic Malignancies and Solid Tumors: A Meta-Analysis |
| title_full_unstemmed | Prognostic Role of the Activated p-AKT Molecule in Various Hematologic Malignancies and Solid Tumors: A Meta-Analysis |
| title_short | Prognostic Role of the Activated p-AKT Molecule in Various Hematologic Malignancies and Solid Tumors: A Meta-Analysis |
| title_sort | prognostic role of the activated p akt molecule in various hematologic malignancies and solid tumors a meta analysis |
| topic | p-AKT tumor meta-analysis oxidative stress biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.588200/full |
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