The role of prostate-specific antigen in the osteoblastic bone metastasis of prostate cancer: a literature review
Prostate cancer is the only human malignancy that generates predominantly osteoblastic bone metastases, and osteoblastic bone metastases account for more than 90% of osseous metastases of prostate cancer. Prostate-specific antigen (PSA) plays an important role in the osteoblastic bone metastasis of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1127637/full |
| _version_ | 1797690513701208064 |
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| author | Xu Zhang Peng Jiang Chaojun Wang |
| author_facet | Xu Zhang Peng Jiang Chaojun Wang |
| author_sort | Xu Zhang |
| collection | DOAJ |
| description | Prostate cancer is the only human malignancy that generates predominantly osteoblastic bone metastases, and osteoblastic bone metastases account for more than 90% of osseous metastases of prostate cancer. Prostate-specific antigen (PSA) plays an important role in the osteoblastic bone metastasis of prostate cancer, which can promote osteomimicry of prostate cancer cells, suppress osteoclast differentiation, and facilitate osteoblast proliferation and activation at metastatic sites. In the meantime, it can activate osteogenic factors, including insulin-like growth factor, transforming growth factor β2 and urokinase-type plasminogen activator, and meanwhile suppress osteolytic factors such as parathyroid hormone-related protein. To recapitulate, PSA plays a significant role in the osteoblastic predominance of prostate cancer bone metastasis and bone remodeling by regulating multiple cells and factors involved in osseous metastasis. |
| first_indexed | 2024-03-12T02:00:37Z |
| format | Article |
| id | doaj.art-c97db73a1b2244f29ab7679225fdcae2 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-12T02:00:37Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c97db73a1b2244f29ab7679225fdcae22023-09-07T18:04:53ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-09-011310.3389/fonc.2023.11276371127637The role of prostate-specific antigen in the osteoblastic bone metastasis of prostate cancer: a literature reviewXu ZhangPeng JiangChaojun WangProstate cancer is the only human malignancy that generates predominantly osteoblastic bone metastases, and osteoblastic bone metastases account for more than 90% of osseous metastases of prostate cancer. Prostate-specific antigen (PSA) plays an important role in the osteoblastic bone metastasis of prostate cancer, which can promote osteomimicry of prostate cancer cells, suppress osteoclast differentiation, and facilitate osteoblast proliferation and activation at metastatic sites. In the meantime, it can activate osteogenic factors, including insulin-like growth factor, transforming growth factor β2 and urokinase-type plasminogen activator, and meanwhile suppress osteolytic factors such as parathyroid hormone-related protein. To recapitulate, PSA plays a significant role in the osteoblastic predominance of prostate cancer bone metastasis and bone remodeling by regulating multiple cells and factors involved in osseous metastasis.https://www.frontiersin.org/articles/10.3389/fonc.2023.1127637/fullprostate-specific antigenosteoblastic bone metastasisosteoclastosteoblastinsulin-like growth factortransforming growth factor β2 |
| spellingShingle | Xu Zhang Peng Jiang Chaojun Wang The role of prostate-specific antigen in the osteoblastic bone metastasis of prostate cancer: a literature review Frontiers in Oncology prostate-specific antigen osteoblastic bone metastasis osteoclast osteoblast insulin-like growth factor transforming growth factor β2 |
| title | The role of prostate-specific antigen in the osteoblastic bone metastasis of prostate cancer: a literature review |
| title_full | The role of prostate-specific antigen in the osteoblastic bone metastasis of prostate cancer: a literature review |
| title_fullStr | The role of prostate-specific antigen in the osteoblastic bone metastasis of prostate cancer: a literature review |
| title_full_unstemmed | The role of prostate-specific antigen in the osteoblastic bone metastasis of prostate cancer: a literature review |
| title_short | The role of prostate-specific antigen in the osteoblastic bone metastasis of prostate cancer: a literature review |
| title_sort | role of prostate specific antigen in the osteoblastic bone metastasis of prostate cancer a literature review |
| topic | prostate-specific antigen osteoblastic bone metastasis osteoclast osteoblast insulin-like growth factor transforming growth factor β2 |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1127637/full |
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