Parkinson's disease constipation effect of electroacupuncture at ST25 through colonic motility and enteric neuropathology
BackgroundThe enteric nervous system (ENS) plays a central role in developing Parkinson's disease (PD) constipation, and the regulation of the ENS may be a key component in treating PD constipation. Electroacupuncture (EA) can effectively treat constipation symptoms in PD, but research on its s...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.1092127/full |
| _version_ | 1797950902311583744 |
|---|---|
| author | Li-zhe-xiong Song Li-zhe-xiong Song Yuan Li Yuan Li Xu Qian Xu Qian Na Xu Na Xu Zhi Yu Zhi Yu Jing-wen Dai Bin Xu Bin Xu Xuan-ming Hu |
| author_facet | Li-zhe-xiong Song Li-zhe-xiong Song Yuan Li Yuan Li Xu Qian Xu Qian Na Xu Na Xu Zhi Yu Zhi Yu Jing-wen Dai Bin Xu Bin Xu Xuan-ming Hu |
| author_sort | Li-zhe-xiong Song |
| collection | DOAJ |
| description | BackgroundThe enteric nervous system (ENS) plays a central role in developing Parkinson's disease (PD) constipation, and the regulation of the ENS may be a key component in treating PD constipation. Electroacupuncture (EA) can effectively treat constipation symptoms in PD, but research on its specific mechanisms, especially in terms of ENS, is relatively lacking. Therefore, we investigated whether EA at ST25 promotes the restoration of ENS structure and colonic motor function in the rotenone-induced PD constipation rat model.MethodsIn this study, we evaluated constipation symptoms by stool characteristics, excretion and water volume, and whole gut transit time and observed colonic motility regulation through colonic motion detection and pathological changes in the colonic myenteric nervous plexus by transmission electron microscopy and immunofluorescence staining.ResultsEA significantly improved the constipation symptoms and positively adjusted the colonic motility in rotenone-induced PD constipation rats. At the same time, EA reversed the rotenone-induced colonic myenteric nervous plexus injury and regulated the ratio of inhibitory and excitatory neurotransmitters.ConclusionOur results indicate that EA treatment of PD constipation may be mediated through the adjustment of ENS. |
| first_indexed | 2024-04-10T22:22:22Z |
| format | Article |
| id | doaj.art-c97e463927bd4724a2505e7ea1d03f26 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T22:22:22Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-c97e463927bd4724a2505e7ea1d03f262023-01-17T16:12:37ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-01-011310.3389/fneur.2022.10921271092127Parkinson's disease constipation effect of electroacupuncture at ST25 through colonic motility and enteric neuropathologyLi-zhe-xiong Song0Li-zhe-xiong Song1Yuan Li2Yuan Li3Xu Qian4Xu Qian5Na Xu6Na Xu7Zhi Yu8Zhi Yu9Jing-wen Dai10Bin Xu11Bin Xu12Xuan-ming Hu13Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, ChinaSchool of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing, ChinaKey Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, ChinaSchool of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing, ChinaKey Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, ChinaSchool of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing, ChinaKey Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, ChinaSchool of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing, ChinaKey Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, ChinaSchool of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing, ChinaKey Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, ChinaKey Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, ChinaSchool of Acupuncture-Moxibustion and Tuina, Nanjing University of Chinese Medicine, Nanjing, ChinaAcupuncture Department, Nanjing Hospital of Traditional Chinese Medicine, Affiliated to Nanjing University of Traditional Chinese Medicine, Nanjing, ChinaBackgroundThe enteric nervous system (ENS) plays a central role in developing Parkinson's disease (PD) constipation, and the regulation of the ENS may be a key component in treating PD constipation. Electroacupuncture (EA) can effectively treat constipation symptoms in PD, but research on its specific mechanisms, especially in terms of ENS, is relatively lacking. Therefore, we investigated whether EA at ST25 promotes the restoration of ENS structure and colonic motor function in the rotenone-induced PD constipation rat model.MethodsIn this study, we evaluated constipation symptoms by stool characteristics, excretion and water volume, and whole gut transit time and observed colonic motility regulation through colonic motion detection and pathological changes in the colonic myenteric nervous plexus by transmission electron microscopy and immunofluorescence staining.ResultsEA significantly improved the constipation symptoms and positively adjusted the colonic motility in rotenone-induced PD constipation rats. At the same time, EA reversed the rotenone-induced colonic myenteric nervous plexus injury and regulated the ratio of inhibitory and excitatory neurotransmitters.ConclusionOur results indicate that EA treatment of PD constipation may be mediated through the adjustment of ENS.https://www.frontiersin.org/articles/10.3389/fneur.2022.1092127/fullParkinson's disease constipationelectroacupunctureenteric nervous systemneuropathologycolonic motility |
| spellingShingle | Li-zhe-xiong Song Li-zhe-xiong Song Yuan Li Yuan Li Xu Qian Xu Qian Na Xu Na Xu Zhi Yu Zhi Yu Jing-wen Dai Bin Xu Bin Xu Xuan-ming Hu Parkinson's disease constipation effect of electroacupuncture at ST25 through colonic motility and enteric neuropathology Frontiers in Neurology Parkinson's disease constipation electroacupuncture enteric nervous system neuropathology colonic motility |
| title | Parkinson's disease constipation effect of electroacupuncture at ST25 through colonic motility and enteric neuropathology |
| title_full | Parkinson's disease constipation effect of electroacupuncture at ST25 through colonic motility and enteric neuropathology |
| title_fullStr | Parkinson's disease constipation effect of electroacupuncture at ST25 through colonic motility and enteric neuropathology |
| title_full_unstemmed | Parkinson's disease constipation effect of electroacupuncture at ST25 through colonic motility and enteric neuropathology |
| title_short | Parkinson's disease constipation effect of electroacupuncture at ST25 through colonic motility and enteric neuropathology |
| title_sort | parkinson s disease constipation effect of electroacupuncture at st25 through colonic motility and enteric neuropathology |
| topic | Parkinson's disease constipation electroacupuncture enteric nervous system neuropathology colonic motility |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.1092127/full |
| work_keys_str_mv | AT lizhexiongsong parkinsonsdiseaseconstipationeffectofelectroacupunctureatst25throughcolonicmotilityandentericneuropathology AT lizhexiongsong parkinsonsdiseaseconstipationeffectofelectroacupunctureatst25throughcolonicmotilityandentericneuropathology AT yuanli parkinsonsdiseaseconstipationeffectofelectroacupunctureatst25throughcolonicmotilityandentericneuropathology AT yuanli parkinsonsdiseaseconstipationeffectofelectroacupunctureatst25throughcolonicmotilityandentericneuropathology AT xuqian parkinsonsdiseaseconstipationeffectofelectroacupunctureatst25throughcolonicmotilityandentericneuropathology AT xuqian parkinsonsdiseaseconstipationeffectofelectroacupunctureatst25throughcolonicmotilityandentericneuropathology AT naxu parkinsonsdiseaseconstipationeffectofelectroacupunctureatst25throughcolonicmotilityandentericneuropathology AT naxu parkinsonsdiseaseconstipationeffectofelectroacupunctureatst25throughcolonicmotilityandentericneuropathology AT zhiyu parkinsonsdiseaseconstipationeffectofelectroacupunctureatst25throughcolonicmotilityandentericneuropathology AT zhiyu parkinsonsdiseaseconstipationeffectofelectroacupunctureatst25throughcolonicmotilityandentericneuropathology AT jingwendai parkinsonsdiseaseconstipationeffectofelectroacupunctureatst25throughcolonicmotilityandentericneuropathology AT binxu parkinsonsdiseaseconstipationeffectofelectroacupunctureatst25throughcolonicmotilityandentericneuropathology AT binxu parkinsonsdiseaseconstipationeffectofelectroacupunctureatst25throughcolonicmotilityandentericneuropathology AT xuanminghu parkinsonsdiseaseconstipationeffectofelectroacupunctureatst25throughcolonicmotilityandentericneuropathology |