Blood Purification in Patients with Sepsis Associated with Acute Kidney Injury: A Narrative Review
Sepsis leads to organ dysfunction. Acute kidney injury, a common type of organ dysfunction, is associated with a high mortality rate in patients with sepsis. Kidney replacement therapy can correct the metabolic, electrolyte, and fluid imbalances caused by acute kidney injury. While this therapy can...
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MDPI AG
2023-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/19/6388 |
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| author | Jun Kamei Masafumi Kanamoto Yutaka Igarashi Kodai Suzuki Kensuke Fujita Tsukasa Kuwana Takayuki Ogura Katsunori Mochizuki Yuki Banshotani Hiroyasu Ishikura Yoshihiko Nakamura J-STAD (Japan Sepsis Treatment and Diagnosis) Study Group |
| author_facet | Jun Kamei Masafumi Kanamoto Yutaka Igarashi Kodai Suzuki Kensuke Fujita Tsukasa Kuwana Takayuki Ogura Katsunori Mochizuki Yuki Banshotani Hiroyasu Ishikura Yoshihiko Nakamura J-STAD (Japan Sepsis Treatment and Diagnosis) Study Group |
| author_sort | Jun Kamei |
| collection | DOAJ |
| description | Sepsis leads to organ dysfunction. Acute kidney injury, a common type of organ dysfunction, is associated with a high mortality rate in patients with sepsis. Kidney replacement therapy can correct the metabolic, electrolyte, and fluid imbalances caused by acute kidney injury. While this therapy can improve outcomes, evidence of its beneficial effects is lacking. Herein, we review the indications for blood purification therapy, including kidney replacement therapy, and the current knowledge regarding acute kidney injury in terms of renal and non-renal indications. While renal indications have been well-documented, indications for blood purification therapy in sepsis (non-renal indications) remain controversial. Excessive inflammation is an important factor in the development of sepsis; blood purification therapy has been shown to reduce inflammatory mediators and improve hemodynamic instability. Given the pathophysiology of sepsis, blood purification therapy may decrease mortality rates in these patients. Further trials are needed in order to establish the effectiveness of blood purification therapy for sepsis. |
| first_indexed | 2024-03-10T21:42:08Z |
| format | Article |
| id | doaj.art-c97eaae31e4541eabe2fe8ee6cf8972a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T21:42:08Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-c97eaae31e4541eabe2fe8ee6cf8972a2023-11-19T14:38:04ZengMDPI AGJournal of Clinical Medicine2077-03832023-10-011219638810.3390/jcm12196388Blood Purification in Patients with Sepsis Associated with Acute Kidney Injury: A Narrative ReviewJun Kamei0Masafumi Kanamoto1Yutaka Igarashi2Kodai Suzuki3Kensuke Fujita4Tsukasa Kuwana5Takayuki Ogura6Katsunori Mochizuki7Yuki Banshotani8Hiroyasu Ishikura9Yoshihiko Nakamura10J-STAD (Japan Sepsis Treatment and Diagnosis) Study GroupDepartment of Primary Care and Emergency Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, JapanDepartment of Anesthesiology, Gunma Prefectural Cardiovascular Center, 3-12, Kameizumi, Gunma 371-0004, JapanDepartment of Emergency and Critical Care Medicine, Nippon Medical School, Tokyo 1138603, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Emergency Medicine and Critical Care Medicine, Saiseikai Utsunomiya Hospital, Tochigi 321-0974, JapanDivision of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, Tokyo 173-8610, JapanDepartment of Emergency Medicine and Critical Care Medicine, Saiseikai Utsunomiya Hospital, Tochigi 321-0974, JapanDepartment of Emergency and Critical Care Medicine, Osaka Medical and Pharmaceutical University, Osaka 569-8686, JapanTajima Emergency & Critical Care Medical Center, Toyooka Hospital, Hyogo 668-8501, JapanDepartment of Emergency and Critical Care Medicine, Fukuoka University Hospital, Fukuoka 814-0180, JapanDepartment of Emergency and Critical Care Medicine, Fukuoka University Hospital, Fukuoka 814-0180, JapanSepsis leads to organ dysfunction. Acute kidney injury, a common type of organ dysfunction, is associated with a high mortality rate in patients with sepsis. Kidney replacement therapy can correct the metabolic, electrolyte, and fluid imbalances caused by acute kidney injury. While this therapy can improve outcomes, evidence of its beneficial effects is lacking. Herein, we review the indications for blood purification therapy, including kidney replacement therapy, and the current knowledge regarding acute kidney injury in terms of renal and non-renal indications. While renal indications have been well-documented, indications for blood purification therapy in sepsis (non-renal indications) remain controversial. Excessive inflammation is an important factor in the development of sepsis; blood purification therapy has been shown to reduce inflammatory mediators and improve hemodynamic instability. Given the pathophysiology of sepsis, blood purification therapy may decrease mortality rates in these patients. Further trials are needed in order to establish the effectiveness of blood purification therapy for sepsis.https://www.mdpi.com/2077-0383/12/19/6388sepsisacute kidney injurykidney replacement therapyrenal indicationnon-renal indication |
| spellingShingle | Jun Kamei Masafumi Kanamoto Yutaka Igarashi Kodai Suzuki Kensuke Fujita Tsukasa Kuwana Takayuki Ogura Katsunori Mochizuki Yuki Banshotani Hiroyasu Ishikura Yoshihiko Nakamura J-STAD (Japan Sepsis Treatment and Diagnosis) Study Group Blood Purification in Patients with Sepsis Associated with Acute Kidney Injury: A Narrative Review Journal of Clinical Medicine sepsis acute kidney injury kidney replacement therapy renal indication non-renal indication |
| title | Blood Purification in Patients with Sepsis Associated with Acute Kidney Injury: A Narrative Review |
| title_full | Blood Purification in Patients with Sepsis Associated with Acute Kidney Injury: A Narrative Review |
| title_fullStr | Blood Purification in Patients with Sepsis Associated with Acute Kidney Injury: A Narrative Review |
| title_full_unstemmed | Blood Purification in Patients with Sepsis Associated with Acute Kidney Injury: A Narrative Review |
| title_short | Blood Purification in Patients with Sepsis Associated with Acute Kidney Injury: A Narrative Review |
| title_sort | blood purification in patients with sepsis associated with acute kidney injury a narrative review |
| topic | sepsis acute kidney injury kidney replacement therapy renal indication non-renal indication |
| url | https://www.mdpi.com/2077-0383/12/19/6388 |
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