Inhaled Glucocorticoid Use and the Risk of Osteoporosis in Asthmatic Patients
Background: Recently many studies have focused on the possible role of corticosteroids inhalation on osteoporosis in asthma patients. This study aimed to determine whether the indicatives of bone formation or resorption are different between asthma patients with healthy subjects. Materials and Metho...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences and Health Services
2017-11-01
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| Series: | Research in Molecular Medicine |
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| Online Access: | http://rmm.mazums.ac.ir/browse.php?a_code=A-10-927-1&slc_lang=en&sid=1 |
| _version_ | 1818242285087752192 |
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| author | Mojtaba Eizadi Mohammad Taghi Goodarzi |
| author_facet | Mojtaba Eizadi Mohammad Taghi Goodarzi |
| author_sort | Mojtaba Eizadi |
| collection | DOAJ |
| description | Background: Recently many studies have focused on the possible role of corticosteroids inhalation on osteoporosis in asthma patients. This study aimed to determine whether the indicatives of bone formation or resorption are different between asthma patients with healthy subjects.
Materials and Methods: To achieve this outcome, twenty one middle-aged asthma patients treated with inhaled corticosteroid and the same number healthy individuals matched for age (38 ± 6.5 years of old) participated in this study by accessible sampling. All subjects were non-trained and no smoker. Serum osteocalcin (OC), alkaline phosphatase (ALP) and cross-linked telopeptides of type I collagen (CTX) were measured to assess and compare bone formation and resorption between 2 groups. An Independent sample T-test was used to compare all variables between asthma and healthy subjects.
Results: Significant differences were not observed in body weight and other anthropometrical markers between 2 groups (p > 0.05). Serum osteocalcin have shown a borderline significant lower in asthma patients than healthy subjects (p = 0.051). ALP was significantly lower in asthma patients than healthy subjects (p = 0.021). But serum CTX levels were higher in asthma patients than in healthy subjects (p=0.014).
Conclusion: Based on these finding, it is appear that inhaled corticosteroid in asthma patients can be affect bone turnover in asthma patients, although more research is needed to further explore any potential link between corticosteroids and osteoporosis.
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| first_indexed | 2024-12-12T13:42:48Z |
| format | Article |
| id | doaj.art-c9803c12ecce43cd88ee442be6a3e144 |
| institution | Directory Open Access Journal |
| issn | 2322-1348 2322-133X |
| language | English |
| last_indexed | 2024-12-12T13:42:48Z |
| publishDate | 2017-11-01 |
| publisher | Mazandaran University of Medical Sciences and Health Services |
| record_format | Article |
| series | Research in Molecular Medicine |
| spelling | doaj.art-c9803c12ecce43cd88ee442be6a3e1442022-12-22T00:22:46ZengMazandaran University of Medical Sciences and Health ServicesResearch in Molecular Medicine2322-13482322-133X2017-11-01544149Inhaled Glucocorticoid Use and the Risk of Osteoporosis in Asthmatic PatientsMojtaba Eizadi0Mohammad Taghi Goodarzi1 1. Department of Exercise Physiology, Saveh Branch, Islamic Azad University, Saveh, Iran. 2. Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan , Iran Background: Recently many studies have focused on the possible role of corticosteroids inhalation on osteoporosis in asthma patients. This study aimed to determine whether the indicatives of bone formation or resorption are different between asthma patients with healthy subjects. Materials and Methods: To achieve this outcome, twenty one middle-aged asthma patients treated with inhaled corticosteroid and the same number healthy individuals matched for age (38 ± 6.5 years of old) participated in this study by accessible sampling. All subjects were non-trained and no smoker. Serum osteocalcin (OC), alkaline phosphatase (ALP) and cross-linked telopeptides of type I collagen (CTX) were measured to assess and compare bone formation and resorption between 2 groups. An Independent sample T-test was used to compare all variables between asthma and healthy subjects. Results: Significant differences were not observed in body weight and other anthropometrical markers between 2 groups (p > 0.05). Serum osteocalcin have shown a borderline significant lower in asthma patients than healthy subjects (p = 0.051). ALP was significantly lower in asthma patients than healthy subjects (p = 0.021). But serum CTX levels were higher in asthma patients than in healthy subjects (p=0.014). Conclusion: Based on these finding, it is appear that inhaled corticosteroid in asthma patients can be affect bone turnover in asthma patients, although more research is needed to further explore any potential link between corticosteroids and osteoporosis. http://rmm.mazums.ac.ir/browse.php?a_code=A-10-927-1&slc_lang=en&sid=1Asthma Bone turnover Osteocalcin Corticosteroid |
| spellingShingle | Mojtaba Eizadi Mohammad Taghi Goodarzi Inhaled Glucocorticoid Use and the Risk of Osteoporosis in Asthmatic Patients Research in Molecular Medicine Asthma Bone turnover Osteocalcin Corticosteroid |
| title | Inhaled Glucocorticoid Use and the Risk of Osteoporosis in Asthmatic Patients |
| title_full | Inhaled Glucocorticoid Use and the Risk of Osteoporosis in Asthmatic Patients |
| title_fullStr | Inhaled Glucocorticoid Use and the Risk of Osteoporosis in Asthmatic Patients |
| title_full_unstemmed | Inhaled Glucocorticoid Use and the Risk of Osteoporosis in Asthmatic Patients |
| title_short | Inhaled Glucocorticoid Use and the Risk of Osteoporosis in Asthmatic Patients |
| title_sort | inhaled glucocorticoid use and the risk of osteoporosis in asthmatic patients |
| topic | Asthma Bone turnover Osteocalcin Corticosteroid |
| url | http://rmm.mazums.ac.ir/browse.php?a_code=A-10-927-1&slc_lang=en&sid=1 |
| work_keys_str_mv | AT mojtabaeizadi inhaledglucocorticoiduseandtheriskofosteoporosisinasthmaticpatients AT mohammadtaghigoodarzi inhaledglucocorticoiduseandtheriskofosteoporosisinasthmaticpatients |