Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats
Abstract Purpose: To investigate the effects of lycopene and resveratrol pretreatment on hepatic hyperplasia in partially hepatectomized rats. Methods: The lycopene group and the resveratrol group received 40 mg/kg/day of lycopene or resveratrol, respectively (dissolved in olive oil or in saline s...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2017-03-01
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| Series: | Acta Cirúrgica Brasileira |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000300194&tlng=en |
| _version_ | 1819106096173809664 |
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| author | Pedro Paulo Barros Gisele Mara Silva Gonçalves Gustavo Henrique da Silva Maria Clara Villaça Dias Bastos Loren Nogaroto Ramos Marilia Marinello Fernandes |
| author_facet | Pedro Paulo Barros Gisele Mara Silva Gonçalves Gustavo Henrique da Silva Maria Clara Villaça Dias Bastos Loren Nogaroto Ramos Marilia Marinello Fernandes |
| author_sort | Pedro Paulo Barros |
| collection | DOAJ |
| description | Abstract Purpose: To investigate the effects of lycopene and resveratrol pretreatment on hepatic hyperplasia in partially hepatectomized rats. Methods: The lycopene group and the resveratrol group received 40 mg/kg/day of lycopene or resveratrol, respectively (dissolved in olive oil or in saline solution, respectively) and administered via a gastric tube for 30 days. The partially hepatectomzed (PH) control groups received saline or olive oil via a gastric tube for 30 days, respectively, and the normal control group received no treatment. Liver tissue and intracardiac blood samples were obtained 24, 36 or 48 h after PH. Results: No areas of fibrosis were detected. No significant changes in mitotic index, in the number of apoptosis events or in aspartate aminotransferase and alanine aminotransferase levels were observed. Conclusions: Lycopene and resveratrol pretreatment did not interfere on hepatic hyperplasia in partially hepatectomized rats. |
| first_indexed | 2024-12-22T02:32:42Z |
| format | Article |
| id | doaj.art-c981016260f94f758a90963872c6e5dc |
| institution | Directory Open Access Journal |
| issn | 0102-8650 |
| language | English |
| last_indexed | 2024-12-22T02:32:42Z |
| publishDate | 2017-03-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj.art-c981016260f94f758a90963872c6e5dc2022-12-21T18:41:51ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira0102-86502017-03-0132319420210.1590/s0102-865020170030000003Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized ratsPedro Paulo BarrosGisele Mara Silva GonçalvesGustavo Henrique da SilvaMaria Clara Villaça Dias BastosLoren Nogaroto RamosMarilia Marinello FernandesAbstract Purpose: To investigate the effects of lycopene and resveratrol pretreatment on hepatic hyperplasia in partially hepatectomized rats. Methods: The lycopene group and the resveratrol group received 40 mg/kg/day of lycopene or resveratrol, respectively (dissolved in olive oil or in saline solution, respectively) and administered via a gastric tube for 30 days. The partially hepatectomzed (PH) control groups received saline or olive oil via a gastric tube for 30 days, respectively, and the normal control group received no treatment. Liver tissue and intracardiac blood samples were obtained 24, 36 or 48 h after PH. Results: No areas of fibrosis were detected. No significant changes in mitotic index, in the number of apoptosis events or in aspartate aminotransferase and alanine aminotransferase levels were observed. Conclusions: Lycopene and resveratrol pretreatment did not interfere on hepatic hyperplasia in partially hepatectomized rats.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000300194&tlng=enAlanine TransaminaseAspartate AminotransferasesApoptosisMitotic IndexRats. |
| spellingShingle | Pedro Paulo Barros Gisele Mara Silva Gonçalves Gustavo Henrique da Silva Maria Clara Villaça Dias Bastos Loren Nogaroto Ramos Marilia Marinello Fernandes Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats Acta Cirúrgica Brasileira Alanine Transaminase Aspartate Aminotransferases Apoptosis Mitotic Index Rats. |
| title | Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats |
| title_full | Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats |
| title_fullStr | Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats |
| title_full_unstemmed | Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats |
| title_short | Lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats |
| title_sort | lycopene and resveratrol pretreatment did not interfere with the liver of hepatectomized rats |
| topic | Alanine Transaminase Aspartate Aminotransferases Apoptosis Mitotic Index Rats. |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502017000300194&tlng=en |
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