| Summary: | <p>Abstract</p> <p>Background</p> <p>The G allele of the CD45 77C/G SNP (rs17612648), which has previously been suggested to be associated with autoimmune disorders, was genotyped in 446 Swedish myasthenia gravis (MG) patients and 2303 matched controls.</p> <p>Results</p> <p>There was no association between the polymorphism and patient group as a whole (<it>p </it>= 0.199), nor with clinical subgroups. Our results add to a growing number of studies unable to find association between the 77C/G polymorphism and autoimmune disorders. One control sample, from an adult blood donor, was homozygous for the G allele, yet negative for a panel of auto-antibodies, representing the first homozygous individual studied in this respect.</p> <p>Conclusions</p> <p>The 77C/G mutation does not predispose to MG, and its role in autoimmunity may have to be re-evaluated.</p>
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