Evaluation of 25(OH) Vitamin D3 with Reference to Magnesium Status and Insulin Resistance in T2DM
Introduction: Calcium is a recognized second messenger implicated in insulin secretion. Vitamin D (1,25-dihydroxycholecalciferol, Calcitriol) plays a role in calcium metabolism. This explains the indirect role of Vitamin D in insulin secretion and insulin sensitivity. Hence, low Vitamin D levels...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-11-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/3568/6-%206578_E(RT)_F(H)_PF1(PUH)_PFA(H)_OLF_PF2(PP).pdf |
| Summary: | Introduction: Calcium is a recognized second messenger implicated
in insulin secretion. Vitamin D (1,25-dihydroxycholecalciferol, Calcitriol)
plays a role in calcium metabolism. This explains the indirect
role of Vitamin D in insulin secretion and insulin sensitivity.
Hence, low Vitamin D levels are implicated in decreased insulin
secretion and increased insulin resistance. In this study, we
tried to find out the probable association of Vitamin D3
, calcium
and magnesium with reference to insulin resistance in type
2 diabetes mellitus (T2DM) cases. It is well documented that
measurement of circulating 25-Hydroxycholecalciferol {25 (OH)
Vitamin D3
} is a marker of total Vitamin D status.
Methodology: We measured 25(OH) Vitamin D3
levels in thirty
T2DM subjects with thirty age and sex matched healthy controls.
We estimated Vitamin D status, calcium and magnesium levels in
the light of insulin resistance. Insulin resistance was measured by
homeostasis model assessment of insulin resistance (HOMA-IR).
Results: Twenty five (OH) Vitamin-D3
level was significantly
low among T2DM cases (12.29+2.32ng/ml) in comparison to
healthy controls (19.55+0.50ng/ml) (p<0.01). The levels of
calcium and magnesium were also significantly low in T2DM
cases as compared to healthy controls (p<0.01).
There was significant negative correlation between Vitamin D
status and insulin levels, and insulin resistance (p<0.01).
Implication: A significant negative correlation between Vitamin
D status and insulin levels suggest that the supplementation of
Vitamin D has the potential to increase insulin sensitivity and
lower the risk of developing type 2 diabetes mellitus. |
|---|---|
| ISSN: | 2249-782X 0973-709X |