Multiple Myeloma Exemplifies a Model of Cancer Based on Tissue Disruption as the Initiator Event
The standard model of multiple myeloma (MM) oncogenesis is based on the genetic instability of MM cells and presents its evolution as the emergence of clones with more and more aggressive genotypes, giving them surviving and proliferating advantage. The micro-environment has a passive role. In contr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2018.00355/full |
| _version_ | 1811301712681500672 |
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| author | Jean-Pascal Capp Régis Bataille |
| author_facet | Jean-Pascal Capp Régis Bataille |
| author_sort | Jean-Pascal Capp |
| collection | DOAJ |
| description | The standard model of multiple myeloma (MM) oncogenesis is based on the genetic instability of MM cells and presents its evolution as the emergence of clones with more and more aggressive genotypes, giving them surviving and proliferating advantage. The micro-environment has a passive role. In contrast, many works have shown that the progression of MM is also characterized by the selection of clones with extended phenotypes able to destroy bone trabeculae, suggesting a major role for early micro-environmental disruption. We present a model of MM oncogenesis in which genetic instability is the consequence of the disruption of normal interactions between plasma cells and their environment, the bone remodeling compartment. These interactions, which normally ensure the stability of the genotypes and phenotypes of normal plasma cells could be disrupted by many factors as soon as the early steps of the disease (MGUS, pre-MGUS states). Therapeutical implications of the model are presented. |
| first_indexed | 2024-04-13T07:13:45Z |
| format | Article |
| id | doaj.art-c983b9e2ce6443e989e3cd44277de22c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T07:13:45Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c983b9e2ce6443e989e3cd44277de22c2022-12-22T02:56:48ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2018-09-01810.3389/fonc.2018.00355407391Multiple Myeloma Exemplifies a Model of Cancer Based on Tissue Disruption as the Initiator EventJean-Pascal Capp0Régis Bataille1LISBP, UMR CNRS 5504, UMR INRA 792, INSA Toulouse, University of Toulouse, Toulouse, FranceFaculty of Medecine, University of Angers, Angers, FranceThe standard model of multiple myeloma (MM) oncogenesis is based on the genetic instability of MM cells and presents its evolution as the emergence of clones with more and more aggressive genotypes, giving them surviving and proliferating advantage. The micro-environment has a passive role. In contrast, many works have shown that the progression of MM is also characterized by the selection of clones with extended phenotypes able to destroy bone trabeculae, suggesting a major role for early micro-environmental disruption. We present a model of MM oncogenesis in which genetic instability is the consequence of the disruption of normal interactions between plasma cells and their environment, the bone remodeling compartment. These interactions, which normally ensure the stability of the genotypes and phenotypes of normal plasma cells could be disrupted by many factors as soon as the early steps of the disease (MGUS, pre-MGUS states). Therapeutical implications of the model are presented.https://www.frontiersin.org/article/10.3389/fonc.2018.00355/fullmultiple myelomaMGUSoncogenesisplasma cellsendosteal nichebone lesion |
| spellingShingle | Jean-Pascal Capp Régis Bataille Multiple Myeloma Exemplifies a Model of Cancer Based on Tissue Disruption as the Initiator Event Frontiers in Oncology multiple myeloma MGUS oncogenesis plasma cells endosteal niche bone lesion |
| title | Multiple Myeloma Exemplifies a Model of Cancer Based on Tissue Disruption as the Initiator Event |
| title_full | Multiple Myeloma Exemplifies a Model of Cancer Based on Tissue Disruption as the Initiator Event |
| title_fullStr | Multiple Myeloma Exemplifies a Model of Cancer Based on Tissue Disruption as the Initiator Event |
| title_full_unstemmed | Multiple Myeloma Exemplifies a Model of Cancer Based on Tissue Disruption as the Initiator Event |
| title_short | Multiple Myeloma Exemplifies a Model of Cancer Based on Tissue Disruption as the Initiator Event |
| title_sort | multiple myeloma exemplifies a model of cancer based on tissue disruption as the initiator event |
| topic | multiple myeloma MGUS oncogenesis plasma cells endosteal niche bone lesion |
| url | https://www.frontiersin.org/article/10.3389/fonc.2018.00355/full |
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