Very High-Frequency Ultrasonography Signs in Bilateral Acute Choroidal Effusion Associated with Systemic Sulphonamide Medications: 2 Cases
Sulphonamides are commonly used in medicine for several purposes; however, they can lead to significant adverse effects, including idiosyncratic reactions and choroidal detachment corresponding to a forward rotation of the iris-lens diaphragm; this could also evolve into acute transient myopia with...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2022-02-01
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| Series: | Case Reports in Ophthalmology |
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| Online Access: | https://www.karger.com/Article/FullText/516860 |
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| author | Antonio Piñeiro Ces Manuel Bande Rodriguez María Rodriguez Blanco Lourdes Peña Madrid María J. Lopez Valladares María J. Blanco Teijeiro |
| author_facet | Antonio Piñeiro Ces Manuel Bande Rodriguez María Rodriguez Blanco Lourdes Peña Madrid María J. Lopez Valladares María J. Blanco Teijeiro |
| author_sort | Antonio Piñeiro Ces |
| collection | DOAJ |
| description | Sulphonamides are commonly used in medicine for several purposes; however, they can lead to significant adverse effects, including idiosyncratic reactions and choroidal detachment corresponding to a forward rotation of the iris-lens diaphragm; this could also evolve into acute transient myopia with possible acute angle closure glaucoma. The risk of such reactions to sulphonamides is approximately 3%. In our communication, we have reported on 2 cases involving patients who suffered choroidal detachments after starting sulphonamide treatments and who were diagnosed with the help of ultrasound biomicroscopy. Patient 1 was an 87-year-old male with bilateral pseudophakia who developed an acute change in vision in both eyes after he started taking chlorthalidone, a classic thiazide diuretic antihypertensive that is characterized by having a sulpha-based group. Patient 2 was a 42-year-old female who developed dramatic visual loss after beginning a new treatment (topiramate) for weight loss. We were able to successfully detect the choroidal detachments in these patients with ultrasound biomicroscopy, which aided us in quickly diagnosing the condition. Subsequently, the drugs were immediately discontinued, and appropriate treatment was administered resulting in the full recovery of both patients. |
| first_indexed | 2024-12-11T10:01:52Z |
| format | Article |
| id | doaj.art-c983ea0e145f4b59889292b282085219 |
| institution | Directory Open Access Journal |
| issn | 1663-2699 |
| language | English |
| last_indexed | 2024-12-11T10:01:52Z |
| publishDate | 2022-02-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Ophthalmology |
| spelling | doaj.art-c983ea0e145f4b59889292b2820852192022-12-22T01:12:07ZengKarger PublishersCase Reports in Ophthalmology1663-26992022-02-01131646910.1159/000516860516860Very High-Frequency Ultrasonography Signs in Bilateral Acute Choroidal Effusion Associated with Systemic Sulphonamide Medications: 2 CasesAntonio Piñeiro Ces0Manuel Bande Rodriguez1María Rodriguez Blanco2Lourdes Peña Madrid3María J. Lopez Valladares4María J. Blanco Teijeiro5Unidad de Retina Quirúrgica y Tumores Intraoculares del Adulto (URQTIA), Área Sanitaria de Santiago de Compostela y Barbanza, Complejo Hospitalario Universitario de Santiago de Compostela, Servizo Galego de Saúde (SERGAS), A Coruña, SpainUnidad de Retina Quirúrgica y Tumores Intraoculares del Adulto (URQTIA), Área Sanitaria de Santiago de Compostela y Barbanza, Complejo Hospitalario Universitario de Santiago de Compostela, Servizo Galego de Saúde (SERGAS), A Coruña, SpainUnidad de Retina Quirúrgica y Tumores Intraoculares del Adulto (URQTIA), Área Sanitaria de Santiago de Compostela y Barbanza, Complejo Hospitalario Universitario de Santiago de Compostela, Servizo Galego de Saúde (SERGAS), A Coruña, SpainUnidad de Retina Quirúrgica y Tumores Intraoculares del Adulto (URQTIA), Área Sanitaria de Santiago de Compostela y Barbanza, Complejo Hospitalario Universitario de Santiago de Compostela, Servizo Galego de Saúde (SERGAS), A Coruña, SpainUnidad de Retina Quirúrgica y Tumores Intraoculares del Adulto (URQTIA), Área Sanitaria de Santiago de Compostela y Barbanza, Complejo Hospitalario Universitario de Santiago de Compostela, Servizo Galego de Saúde (SERGAS), A Coruña, SpainUnidad de Retina Quirúrgica y Tumores Intraoculares del Adulto (URQTIA), Área Sanitaria de Santiago de Compostela y Barbanza, Complejo Hospitalario Universitario de Santiago de Compostela, Servizo Galego de Saúde (SERGAS), A Coruña, SpainSulphonamides are commonly used in medicine for several purposes; however, they can lead to significant adverse effects, including idiosyncratic reactions and choroidal detachment corresponding to a forward rotation of the iris-lens diaphragm; this could also evolve into acute transient myopia with possible acute angle closure glaucoma. The risk of such reactions to sulphonamides is approximately 3%. In our communication, we have reported on 2 cases involving patients who suffered choroidal detachments after starting sulphonamide treatments and who were diagnosed with the help of ultrasound biomicroscopy. Patient 1 was an 87-year-old male with bilateral pseudophakia who developed an acute change in vision in both eyes after he started taking chlorthalidone, a classic thiazide diuretic antihypertensive that is characterized by having a sulpha-based group. Patient 2 was a 42-year-old female who developed dramatic visual loss after beginning a new treatment (topiramate) for weight loss. We were able to successfully detect the choroidal detachments in these patients with ultrasound biomicroscopy, which aided us in quickly diagnosing the condition. Subsequently, the drugs were immediately discontinued, and appropriate treatment was administered resulting in the full recovery of both patients.https://www.karger.com/Article/FullText/516860acute angle closurechoroidal effusionglaucomaimagingsulphonamide drugs |
| spellingShingle | Antonio Piñeiro Ces Manuel Bande Rodriguez María Rodriguez Blanco Lourdes Peña Madrid María J. Lopez Valladares María J. Blanco Teijeiro Very High-Frequency Ultrasonography Signs in Bilateral Acute Choroidal Effusion Associated with Systemic Sulphonamide Medications: 2 Cases Case Reports in Ophthalmology acute angle closure choroidal effusion glaucoma imaging sulphonamide drugs |
| title | Very High-Frequency Ultrasonography Signs in Bilateral Acute Choroidal Effusion Associated with Systemic Sulphonamide Medications: 2 Cases |
| title_full | Very High-Frequency Ultrasonography Signs in Bilateral Acute Choroidal Effusion Associated with Systemic Sulphonamide Medications: 2 Cases |
| title_fullStr | Very High-Frequency Ultrasonography Signs in Bilateral Acute Choroidal Effusion Associated with Systemic Sulphonamide Medications: 2 Cases |
| title_full_unstemmed | Very High-Frequency Ultrasonography Signs in Bilateral Acute Choroidal Effusion Associated with Systemic Sulphonamide Medications: 2 Cases |
| title_short | Very High-Frequency Ultrasonography Signs in Bilateral Acute Choroidal Effusion Associated with Systemic Sulphonamide Medications: 2 Cases |
| title_sort | very high frequency ultrasonography signs in bilateral acute choroidal effusion associated with systemic sulphonamide medications 2 cases |
| topic | acute angle closure choroidal effusion glaucoma imaging sulphonamide drugs |
| url | https://www.karger.com/Article/FullText/516860 |
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