Impact of Lumbar Surgery on Pharmacological Treatment for Patients with Lumbar Spinal Canal Stenosis: A Single-Center Retrospective Study
Treatment for lumbar spinal canal stenosis (LSCS) is mainly classified into conservative and surgical therapies. Among conservative therapies, pharmacological treatment is commonly prescribed for LSCS. Meanwhile, surgical treatment is the last option for LSCS. This study aimed to examine the impact...
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MDPI AG
2023-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/6/2385 |
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| author | Takaya Imai Sota Nagai Takehiro Michikawa Risa Inagaki Soya Kawabata Kaori Ito Kurenai Hachiya Hiroki Takeda Daiki Ikeda Shigeki Yamada Nobuyuki Fujita Shinjiro Kaneko |
| author_facet | Takaya Imai Sota Nagai Takehiro Michikawa Risa Inagaki Soya Kawabata Kaori Ito Kurenai Hachiya Hiroki Takeda Daiki Ikeda Shigeki Yamada Nobuyuki Fujita Shinjiro Kaneko |
| author_sort | Takaya Imai |
| collection | DOAJ |
| description | Treatment for lumbar spinal canal stenosis (LSCS) is mainly classified into conservative and surgical therapies. Among conservative therapies, pharmacological treatment is commonly prescribed for LSCS. Meanwhile, surgical treatment is the last option for LSCS. This study aimed to examine the impact of lumbar surgery on pharmacological treatment for patients with LSCS. Consecutive patients aged ≥ 40 years who underwent lumbar surgery for LSCS were identified. A total of 142 patients were retrospectively reviewed for preoperative and 6-month and 1-year postoperative LSCS medications. The results showed that the number of LSCS medications significantly decreased after lumbar surgery. The proportion of the patients taking non-steroidal anti-inflammatory drugs, pregabalin/mirogabalin, opioids, prostaglandin E1 analogs, and neurotropin was significantly decreased after lumbar surgery, but that of the patients taking mecobalamin, acetaminophen, and serotonin-noradrenalin reuptake inhibitors was not significantly changed. Additionally, around 15% of the participants showed an increase in LSCS medications even after lumbar surgery. Multivariable analysis revealed that individuals without improvements in walking ability (RR: 2.7, 95% CI: 1.3–5.9) or social life (RR: 2.3, 95% CI: 1.1–5.0) had a greater risk of a postoperative increase in LSCS medications. The study results may provide physicians with beneficial information on treatment for LSCS. |
| first_indexed | 2024-03-11T06:22:28Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T06:22:28Z |
| publishDate | 2023-03-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-c984688f74a34c798c5a78b904f19f052023-11-17T11:52:09ZengMDPI AGJournal of Clinical Medicine2077-03832023-03-01126238510.3390/jcm12062385Impact of Lumbar Surgery on Pharmacological Treatment for Patients with Lumbar Spinal Canal Stenosis: A Single-Center Retrospective StudyTakaya Imai0Sota Nagai1Takehiro Michikawa2Risa Inagaki3Soya Kawabata4Kaori Ito5Kurenai Hachiya6Hiroki Takeda7Daiki Ikeda8Shigeki Yamada9Nobuyuki Fujita10Shinjiro Kaneko11Department of Orthopaedic Surgery, School of Medicine, Fujita Health University, Toyoake 470-1192, JapanDepartment of Orthopaedic Surgery, School of Medicine, Fujita Health University, Toyoake 470-1192, JapanDepartment of Environmental and Occupational Health, School of Medicine, Toho University, Tokyo 143-8541, JapanDepartment of Clinical Pharmacy, School of Medicine, Fujita Health University, Toyoake 470-1192, JapanDepartment of Orthopaedic Surgery, School of Medicine, Fujita Health University, Toyoake 470-1192, JapanDepartment of Clinical Pharmacy, School of Medicine, Fujita Health University, Toyoake 470-1192, JapanDepartment of Orthopaedic Surgery, School of Medicine, Fujita Health University, Toyoake 470-1192, JapanDepartment of Spine and Spinal Cord Surgery, Fujita Health University, Toyoake 470-1192, JapanDepartment of Orthopaedic Surgery, School of Medicine, Fujita Health University, Toyoake 470-1192, JapanDepartment of Clinical Pharmacy, School of Medicine, Fujita Health University, Toyoake 470-1192, JapanDepartment of Orthopaedic Surgery, School of Medicine, Fujita Health University, Toyoake 470-1192, JapanDepartment of Spine and Spinal Cord Surgery, Fujita Health University, Toyoake 470-1192, JapanTreatment for lumbar spinal canal stenosis (LSCS) is mainly classified into conservative and surgical therapies. Among conservative therapies, pharmacological treatment is commonly prescribed for LSCS. Meanwhile, surgical treatment is the last option for LSCS. This study aimed to examine the impact of lumbar surgery on pharmacological treatment for patients with LSCS. Consecutive patients aged ≥ 40 years who underwent lumbar surgery for LSCS were identified. A total of 142 patients were retrospectively reviewed for preoperative and 6-month and 1-year postoperative LSCS medications. The results showed that the number of LSCS medications significantly decreased after lumbar surgery. The proportion of the patients taking non-steroidal anti-inflammatory drugs, pregabalin/mirogabalin, opioids, prostaglandin E1 analogs, and neurotropin was significantly decreased after lumbar surgery, but that of the patients taking mecobalamin, acetaminophen, and serotonin-noradrenalin reuptake inhibitors was not significantly changed. Additionally, around 15% of the participants showed an increase in LSCS medications even after lumbar surgery. Multivariable analysis revealed that individuals without improvements in walking ability (RR: 2.7, 95% CI: 1.3–5.9) or social life (RR: 2.3, 95% CI: 1.1–5.0) had a greater risk of a postoperative increase in LSCS medications. The study results may provide physicians with beneficial information on treatment for LSCS.https://www.mdpi.com/2077-0383/12/6/2385lumbar spinal canal stenosislumbar surgerypharmacological treatmentRoland-Morris Disability QuestionnaireZurich Claudication QuestionnaireJapanese Orthopaedic Association Back Pain Evaluation Questionnaire |
| spellingShingle | Takaya Imai Sota Nagai Takehiro Michikawa Risa Inagaki Soya Kawabata Kaori Ito Kurenai Hachiya Hiroki Takeda Daiki Ikeda Shigeki Yamada Nobuyuki Fujita Shinjiro Kaneko Impact of Lumbar Surgery on Pharmacological Treatment for Patients with Lumbar Spinal Canal Stenosis: A Single-Center Retrospective Study Journal of Clinical Medicine lumbar spinal canal stenosis lumbar surgery pharmacological treatment Roland-Morris Disability Questionnaire Zurich Claudication Questionnaire Japanese Orthopaedic Association Back Pain Evaluation Questionnaire |
| title | Impact of Lumbar Surgery on Pharmacological Treatment for Patients with Lumbar Spinal Canal Stenosis: A Single-Center Retrospective Study |
| title_full | Impact of Lumbar Surgery on Pharmacological Treatment for Patients with Lumbar Spinal Canal Stenosis: A Single-Center Retrospective Study |
| title_fullStr | Impact of Lumbar Surgery on Pharmacological Treatment for Patients with Lumbar Spinal Canal Stenosis: A Single-Center Retrospective Study |
| title_full_unstemmed | Impact of Lumbar Surgery on Pharmacological Treatment for Patients with Lumbar Spinal Canal Stenosis: A Single-Center Retrospective Study |
| title_short | Impact of Lumbar Surgery on Pharmacological Treatment for Patients with Lumbar Spinal Canal Stenosis: A Single-Center Retrospective Study |
| title_sort | impact of lumbar surgery on pharmacological treatment for patients with lumbar spinal canal stenosis a single center retrospective study |
| topic | lumbar spinal canal stenosis lumbar surgery pharmacological treatment Roland-Morris Disability Questionnaire Zurich Claudication Questionnaire Japanese Orthopaedic Association Back Pain Evaluation Questionnaire |
| url | https://www.mdpi.com/2077-0383/12/6/2385 |
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