Group A Streptococcus Vaccine Targeting the Erythrogenic Toxins SpeA and SpeB Is Safe and Immunogenic in Rabbits and Does Not Induce Antibodies Associated with Autoimmunity

Group A Streptococcus Vaccine Targeting the Erythrogenic Toxins SpeA and SpeB Is Safe and Immunogenic in Rabbits and Does Not Induce Antibodies Associated with Autoimmunity

Group A streptococcus (GAS) is a global pathogen associated with significant morbidity and mortality for which there is currently no licensed vaccine. Vaccine development has been slow, mostly due to safety concerns regarding streptococcal antigens associated with autoimmunity and related complicati...

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Bibliographic Details
Main Authors: Matthew J. Troese, Elodie Burlet, Madeleine W. Cunningham, Kathy Alvarez, Rebecca Bentley, Nissy Thomas, Shanna Carwell, Garry L. Morefield
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Vaccines
Subjects:
Group A Streptococcus (GAS)
<i>Streptococcus pyogenes</i>
SpeA
SpeB
vaccine
safety
Online Access:https://www.mdpi.com/2076-393X/11/9/1504

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