Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition

Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition

Abstract Background Accumulating evidence has highlighted the importance of microglial and astrocyte responses in the pathological development of postoperative cognitive dysfunction (POCD). However, the mechanisms involved are not well understood. Methods A perioperative neurocognitive disorders (PN...

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Bibliographic Details
Main Authors: Dongliang Li, Mingming Chen, Tao Meng, Jianchun Fei
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Neuroinflammation
Subjects:
General anesthetics
Inflammation
Synaptic plasticity
IPSC
EPSC
magnetic-activated cell-sorting
Online Access:http://link.springer.com/article/10.1186/s12974-020-01799-0

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