Overcoming addition of phosphoethanolamine to lipid A mediated colistin resistance in Acinetobacter baumannii clinical isolates with colistin–sulbactam combination therapy

Overcoming addition of phosphoethanolamine to lipid A mediated colistin resistance in Acinetobacter baumannii clinical isolates with colistin–sulbactam combination therapy

Abstract Overcoming colistin-resistant Acinetobacter baumannii (CoR-AB) has become a major concern due to the lack of effective antibiotics. This study aimed to explore the prevalence of CoR-AB clinical isolates in Thailand, their mechanisms of resistance, and test the efficacy of colistin plus sulb...

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Bibliographic Details
Main Authors: Sukrit Srisakul, Dhammika Leshan Wannigama, Paul G. Higgins, Cameron Hurst, Shuichi Abe, Parichart Hongsing, Thammakorn Saethang, Sirirat Luk-in, Tingting Liao, Naris Kueakulpattana, Aye Mya Sithu Shein, Lin Gan, Rosalyn Kupwiwat, Chanikan Tanasatitchai, Pattama Wapeesittipan, Phatthranit Phattharapornjaroen, Vishnu Nayak Badavath, Asada Leelahavanichkul, Tanittha Chatsuwan
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-15386-1

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