A coordinate deregulation of microRNAs expressed in mucosa adjacent to tumor predicts relapse after resection in localized colon cancer
Abstract Up to 20% of colorectal cancer (CRC) node-negative patients develop loco-regional or distant recurrences within 5 years from surgery. No predictive biomarker able to identify the node-negative subjects at high risk of relapse after curative treatment is presently available. Forty-eight loca...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-01-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12943-018-0770-8 |
| _version_ | 1819034632603041792 |
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| author | Angela Grassi Lisa Perilli Laura Albertoni Sofia Tessarollo Claudia Mescoli Emanuele D. L. Urso Matteo Fassan Massimo Rugge Paola Zanovello |
| author_facet | Angela Grassi Lisa Perilli Laura Albertoni Sofia Tessarollo Claudia Mescoli Emanuele D. L. Urso Matteo Fassan Massimo Rugge Paola Zanovello |
| author_sort | Angela Grassi |
| collection | DOAJ |
| description | Abstract Up to 20% of colorectal cancer (CRC) node-negative patients develop loco-regional or distant recurrences within 5 years from surgery. No predictive biomarker able to identify the node-negative subjects at high risk of relapse after curative treatment is presently available. Forty-eight localized (i.e. stage I-II) colon cancer patients who underwent radical tumor resection were considered. The expression of five miRNAs, involved in CRC progression, was investigated by qRT-PCR in both tumor tissue and matched normal colon mucosa. Interestingly, we found that the coordinate deregulation of four miRNAs (i.e. miR-18a, miR-21, miR-182 and miR-183), evaluated in the normal mucosa adjacent to tumor, is predictive of relapse within 55 months from curative surgery. Our results, if confirmed in independent studies, may help to identify high-risk patients who could benefit most from adjuvant therapy. Moreover, this work highlights the importance of extending the search for tissue biomarkers also to the tumor-adjacent mucosa. |
| first_indexed | 2024-12-21T07:36:49Z |
| format | Article |
| id | doaj.art-c98e741851cd487cb5da287278e25cf1 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-21T07:36:49Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-c98e741851cd487cb5da287278e25cf12022-12-21T19:11:27ZengBMCMolecular Cancer1476-45982018-01-011711510.1186/s12943-018-0770-8A coordinate deregulation of microRNAs expressed in mucosa adjacent to tumor predicts relapse after resection in localized colon cancerAngela Grassi0Lisa Perilli1Laura Albertoni2Sofia Tessarollo3Claudia Mescoli4Emanuele D. L. Urso5Matteo Fassan6Massimo Rugge7Paola Zanovello8Istituto Oncologico Veneto IOV – IRCCSIstituto Oncologico Veneto IOV – IRCCSSurgical Pathology and Cytopathology Unit, Department of Medicine DIMED, University of PadovaDepartment of Surgery, Oncology and Gastroenterology, University of PadovaSurgical Pathology and Cytopathology Unit, Department of Medicine DIMED, University of PadovaAzienda Ospedaliera-Università degli Studi di PadovaSurgical Pathology and Cytopathology Unit, Department of Medicine DIMED, University of PadovaSurgical Pathology and Cytopathology Unit, Department of Medicine DIMED, University of PadovaIstituto Oncologico Veneto IOV – IRCCSAbstract Up to 20% of colorectal cancer (CRC) node-negative patients develop loco-regional or distant recurrences within 5 years from surgery. No predictive biomarker able to identify the node-negative subjects at high risk of relapse after curative treatment is presently available. Forty-eight localized (i.e. stage I-II) colon cancer patients who underwent radical tumor resection were considered. The expression of five miRNAs, involved in CRC progression, was investigated by qRT-PCR in both tumor tissue and matched normal colon mucosa. Interestingly, we found that the coordinate deregulation of four miRNAs (i.e. miR-18a, miR-21, miR-182 and miR-183), evaluated in the normal mucosa adjacent to tumor, is predictive of relapse within 55 months from curative surgery. Our results, if confirmed in independent studies, may help to identify high-risk patients who could benefit most from adjuvant therapy. Moreover, this work highlights the importance of extending the search for tissue biomarkers also to the tumor-adjacent mucosa.http://link.springer.com/article/10.1186/s12943-018-0770-8microRNAslocalized colon cancerrelapsepredictive markersadjacent mucosa |
| spellingShingle | Angela Grassi Lisa Perilli Laura Albertoni Sofia Tessarollo Claudia Mescoli Emanuele D. L. Urso Matteo Fassan Massimo Rugge Paola Zanovello A coordinate deregulation of microRNAs expressed in mucosa adjacent to tumor predicts relapse after resection in localized colon cancer Molecular Cancer microRNAs localized colon cancer relapse predictive markers adjacent mucosa |
| title | A coordinate deregulation of microRNAs expressed in mucosa adjacent to tumor predicts relapse after resection in localized colon cancer |
| title_full | A coordinate deregulation of microRNAs expressed in mucosa adjacent to tumor predicts relapse after resection in localized colon cancer |
| title_fullStr | A coordinate deregulation of microRNAs expressed in mucosa adjacent to tumor predicts relapse after resection in localized colon cancer |
| title_full_unstemmed | A coordinate deregulation of microRNAs expressed in mucosa adjacent to tumor predicts relapse after resection in localized colon cancer |
| title_short | A coordinate deregulation of microRNAs expressed in mucosa adjacent to tumor predicts relapse after resection in localized colon cancer |
| title_sort | coordinate deregulation of micrornas expressed in mucosa adjacent to tumor predicts relapse after resection in localized colon cancer |
| topic | microRNAs localized colon cancer relapse predictive markers adjacent mucosa |
| url | http://link.springer.com/article/10.1186/s12943-018-0770-8 |
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