The transcription factor Zfp503 promotes the D1 MSN identity and represses the D2 MSN identity

The transcription factor Zfp503 promotes the D1 MSN identity and represses the D2 MSN identity

The striatum is primarily composed of two types of medium spiny neurons (MSNs) expressing either D1- or D2-type dopamine receptors. However, the fate determination of these two types of neurons is not fully understood. Here, we found that D1 MSNs undergo fate switching to D2 MSNs in the absence of Z...

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Bibliographic Details
Main Authors: Zicong Shang, Lin Yang, Ziwu Wang, Yu Tian, Yanjing Gao, Zihao Su, Rongliang Guo, Weiwei Li, Guoping Liu, Xiaosu Li, Zhengang Yang, Zhenmeiyu Li, Zhuangzhi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ZFP503
striatum
fate switch
LGE
medium-sized spiny neurons
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.948331/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.948331/full

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