Fabrication of Ropivacaine/Dexamethasone-Eluting Poly(D, L-lactide-co-glycolide) Microparticles via Electrospraying Technique for Postoperational Pain Control
Microencapsulation plays an important role in biomedical technology owing to its particular and attractive characteristics. In this work, we developed ropivacaine and dexamethasone loaded poly(D, L-lactide-co-glycolide) (PLGA) microparticles via electrospraying technique and investigated the release...
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| Format: | Article |
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MDPI AG
2022-02-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/4/702 |
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| author | Shih-Jyun Shen Ying-Chao Chou Shih-Chieh Hsu Yu-Ting Lin Chia-Jung Lu Shih-Jung Liu |
| author_facet | Shih-Jyun Shen Ying-Chao Chou Shih-Chieh Hsu Yu-Ting Lin Chia-Jung Lu Shih-Jung Liu |
| author_sort | Shih-Jyun Shen |
| collection | DOAJ |
| description | Microencapsulation plays an important role in biomedical technology owing to its particular and attractive characteristics. In this work, we developed ropivacaine and dexamethasone loaded poly(D, L-lactide-co-glycolide) (PLGA) microparticles via electrospraying technique and investigated the release behavior of electrosprayed microparticles. The particle morphology of sprayed particles was assessed using scanning electron microscopy (SEM). The in vitro drug release kinetics were evaluated employing an elution method, and the in vivo pharmaceutical release as well as its efficacy on pain relief were tested using an animal activity model. The microscopic observation suggested that sprayed microparticles exhibit a size distribution of 5–6 µm. Fourier-transform infrared spectrometry and differential scanning calorimetry demonstrated the successful incorporation of pharmaceuticals in the PLGA particulates. The drugs-loaded particles discharged sustainably high concentrations of ropivacaine and dexamethasone at the target region in vivo for over two weeks, and the drug levels in the blood remained low. By adopting the electrospraying technique, we were able to prepare drug-embedded polymeric microparticles with effectiveness and with a sustainable capability for postoperative pain control. |
| first_indexed | 2024-03-09T21:12:25Z |
| format | Article |
| id | doaj.art-c98f28435fb944a29125db456c2eacc2 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T21:12:25Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-c98f28435fb944a29125db456c2eacc22023-11-23T21:44:28ZengMDPI AGPolymers2073-43602022-02-0114470210.3390/polym14040702Fabrication of Ropivacaine/Dexamethasone-Eluting Poly(D, L-lactide-co-glycolide) Microparticles via Electrospraying Technique for Postoperational Pain ControlShih-Jyun Shen0Ying-Chao Chou1Shih-Chieh Hsu2Yu-Ting Lin3Chia-Jung Lu4Shih-Jung Liu5Department of Mechanical Engineering, Chang Gung University, Taoyuan 33302, TaiwanDepartment of Orthopedic Surgery, Bone and Joint Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, TaiwanDepartment of Mechanical Engineering, Chang Gung University, Taoyuan 33302, TaiwanDepartment of Mechanical Engineering, Chang Gung University, Taoyuan 33302, TaiwanDepartment of Mechanical Engineering, Chang Gung University, Taoyuan 33302, TaiwanDepartment of Mechanical Engineering, Chang Gung University, Taoyuan 33302, TaiwanMicroencapsulation plays an important role in biomedical technology owing to its particular and attractive characteristics. In this work, we developed ropivacaine and dexamethasone loaded poly(D, L-lactide-co-glycolide) (PLGA) microparticles via electrospraying technique and investigated the release behavior of electrosprayed microparticles. The particle morphology of sprayed particles was assessed using scanning electron microscopy (SEM). The in vitro drug release kinetics were evaluated employing an elution method, and the in vivo pharmaceutical release as well as its efficacy on pain relief were tested using an animal activity model. The microscopic observation suggested that sprayed microparticles exhibit a size distribution of 5–6 µm. Fourier-transform infrared spectrometry and differential scanning calorimetry demonstrated the successful incorporation of pharmaceuticals in the PLGA particulates. The drugs-loaded particles discharged sustainably high concentrations of ropivacaine and dexamethasone at the target region in vivo for over two weeks, and the drug levels in the blood remained low. By adopting the electrospraying technique, we were able to prepare drug-embedded polymeric microparticles with effectiveness and with a sustainable capability for postoperative pain control.https://www.mdpi.com/2073-4360/14/4/702electrosprayingmicroparticlesropivacainedexamethasonesustained release |
| spellingShingle | Shih-Jyun Shen Ying-Chao Chou Shih-Chieh Hsu Yu-Ting Lin Chia-Jung Lu Shih-Jung Liu Fabrication of Ropivacaine/Dexamethasone-Eluting Poly(D, L-lactide-co-glycolide) Microparticles via Electrospraying Technique for Postoperational Pain Control Polymers electrospraying microparticles ropivacaine dexamethasone sustained release |
| title | Fabrication of Ropivacaine/Dexamethasone-Eluting Poly(D, L-lactide-co-glycolide) Microparticles via Electrospraying Technique for Postoperational Pain Control |
| title_full | Fabrication of Ropivacaine/Dexamethasone-Eluting Poly(D, L-lactide-co-glycolide) Microparticles via Electrospraying Technique for Postoperational Pain Control |
| title_fullStr | Fabrication of Ropivacaine/Dexamethasone-Eluting Poly(D, L-lactide-co-glycolide) Microparticles via Electrospraying Technique for Postoperational Pain Control |
| title_full_unstemmed | Fabrication of Ropivacaine/Dexamethasone-Eluting Poly(D, L-lactide-co-glycolide) Microparticles via Electrospraying Technique for Postoperational Pain Control |
| title_short | Fabrication of Ropivacaine/Dexamethasone-Eluting Poly(D, L-lactide-co-glycolide) Microparticles via Electrospraying Technique for Postoperational Pain Control |
| title_sort | fabrication of ropivacaine dexamethasone eluting poly d l lactide co glycolide microparticles via electrospraying technique for postoperational pain control |
| topic | electrospraying microparticles ropivacaine dexamethasone sustained release |
| url | https://www.mdpi.com/2073-4360/14/4/702 |
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