Non-HDL-cholesterol as valid surrogate to apolipoprotein B<sub>100 </sub>measurement in diabetes: Discriminant Ratio and unbiased equivalence
<p>Abstract</p> <p>Background</p> <p>Apolipoprotein B<sub>100 </sub>(apoB) is a superior indicator of CV risk than total or LDL-C. Non-HDL-C represents a simple surrogate for apoB in hypertriglyceridemic and/or T2DM patients. ApoB and non-HDL-C show high cor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-02-01
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| Series: | Cardiovascular Diabetology |
| Online Access: | http://www.cardiab.com/content/10/1/20 |
| _version_ | 1818995615329157120 |
|---|---|
| author | Ahn Sylvie A Sacks Frank M Hermans Michel P Rousseau Michel F |
| author_facet | Ahn Sylvie A Sacks Frank M Hermans Michel P Rousseau Michel F |
| author_sort | Ahn Sylvie A |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Apolipoprotein B<sub>100 </sub>(apoB) is a superior indicator of CV risk than total or LDL-C. Non-HDL-C represents a simple surrogate for apoB in hypertriglyceridemic and/or T2DM patients. ApoB and non-HDL-C show high correlation, although the degree of mutual concordance remains debated in CV risk evaluation.</p> <p>Objectives</p> <p>We used the <it>Discriminant Ratio </it>(DR) methodology to compare the performance of non-HDL-C with that of apoB to rank diabetic patients according to dyslipidemia and to establish the underlying relationship between these variables taking measurement noise and intra-/intersubject variation into account, and to derive an unbiased equivalence equation.</p> <p>Methods</p> <p>Fasting total C, HDL-C, apoB and triglycerides were measured in 45 diabetic patients. The DR of the underlying between-subject standard deviation (SD) to the within-subject SD was calculated from duplicates. Correlation coefficients between pairs were adjusted to include an estimate of the underlying correlation.</p> <p>Results</p> <p>Mean values [day 1 (1SD)] were 143 (36) mg/dl (non-HDL-C) and 98 (24) mg/dl (apoB). The DR's of both parameters were similar (1.76 and 1.83) (p = 0.83). Pearson's product-moment correlation coefficient between tests was very high (0.94), reaching unity (1.00) after attenuation adjustment. The unbiased equation of equivalence relating apoB to non-HDL-C had a slope of 0.65 and an intercept of 6.3 mg/dl.</p> <p>Conclusions</p> <p>The discrimination power of non-HDL-C is similar to that of apoB to rank diabetic patients according to atherogenic cholesterol and lipoprotein burden. Since true correlation between variables reached unity, non-HDL-C may provide not only a metabolic surrogate but also a candidate biometrical equivalent to apoB, as non-HDL-C calculation is readily available.</p> |
| first_indexed | 2024-12-20T21:16:39Z |
| format | Article |
| id | doaj.art-c99010fb8496486a9aa43253f3cf1763 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-20T21:16:39Z |
| publishDate | 2011-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-c99010fb8496486a9aa43253f3cf17632022-12-21T19:26:25ZengBMCCardiovascular Diabetology1475-28402011-02-011012010.1186/1475-2840-10-20Non-HDL-cholesterol as valid surrogate to apolipoprotein B<sub>100 </sub>measurement in diabetes: Discriminant Ratio and unbiased equivalenceAhn Sylvie ASacks Frank MHermans Michel PRousseau Michel F<p>Abstract</p> <p>Background</p> <p>Apolipoprotein B<sub>100 </sub>(apoB) is a superior indicator of CV risk than total or LDL-C. Non-HDL-C represents a simple surrogate for apoB in hypertriglyceridemic and/or T2DM patients. ApoB and non-HDL-C show high correlation, although the degree of mutual concordance remains debated in CV risk evaluation.</p> <p>Objectives</p> <p>We used the <it>Discriminant Ratio </it>(DR) methodology to compare the performance of non-HDL-C with that of apoB to rank diabetic patients according to dyslipidemia and to establish the underlying relationship between these variables taking measurement noise and intra-/intersubject variation into account, and to derive an unbiased equivalence equation.</p> <p>Methods</p> <p>Fasting total C, HDL-C, apoB and triglycerides were measured in 45 diabetic patients. The DR of the underlying between-subject standard deviation (SD) to the within-subject SD was calculated from duplicates. Correlation coefficients between pairs were adjusted to include an estimate of the underlying correlation.</p> <p>Results</p> <p>Mean values [day 1 (1SD)] were 143 (36) mg/dl (non-HDL-C) and 98 (24) mg/dl (apoB). The DR's of both parameters were similar (1.76 and 1.83) (p = 0.83). Pearson's product-moment correlation coefficient between tests was very high (0.94), reaching unity (1.00) after attenuation adjustment. The unbiased equation of equivalence relating apoB to non-HDL-C had a slope of 0.65 and an intercept of 6.3 mg/dl.</p> <p>Conclusions</p> <p>The discrimination power of non-HDL-C is similar to that of apoB to rank diabetic patients according to atherogenic cholesterol and lipoprotein burden. Since true correlation between variables reached unity, non-HDL-C may provide not only a metabolic surrogate but also a candidate biometrical equivalent to apoB, as non-HDL-C calculation is readily available.</p>http://www.cardiab.com/content/10/1/20 |
| spellingShingle | Ahn Sylvie A Sacks Frank M Hermans Michel P Rousseau Michel F Non-HDL-cholesterol as valid surrogate to apolipoprotein B<sub>100 </sub>measurement in diabetes: Discriminant Ratio and unbiased equivalence Cardiovascular Diabetology |
| title | Non-HDL-cholesterol as valid surrogate to apolipoprotein B<sub>100 </sub>measurement in diabetes: Discriminant Ratio and unbiased equivalence |
| title_full | Non-HDL-cholesterol as valid surrogate to apolipoprotein B<sub>100 </sub>measurement in diabetes: Discriminant Ratio and unbiased equivalence |
| title_fullStr | Non-HDL-cholesterol as valid surrogate to apolipoprotein B<sub>100 </sub>measurement in diabetes: Discriminant Ratio and unbiased equivalence |
| title_full_unstemmed | Non-HDL-cholesterol as valid surrogate to apolipoprotein B<sub>100 </sub>measurement in diabetes: Discriminant Ratio and unbiased equivalence |
| title_short | Non-HDL-cholesterol as valid surrogate to apolipoprotein B<sub>100 </sub>measurement in diabetes: Discriminant Ratio and unbiased equivalence |
| title_sort | non hdl cholesterol as valid surrogate to apolipoprotein b sub 100 sub measurement in diabetes discriminant ratio and unbiased equivalence |
| url | http://www.cardiab.com/content/10/1/20 |
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