Activation-induced pyroptosis contributes to the loss of MAIT cells in chronic HIV-1 infected patients

Activation-induced pyroptosis contributes to the loss of MAIT cells in chronic HIV-1 infected patients

Abstract Background Mucosal-associated invariant T (MAIT) cells are systemically depleted in human immunodeficiency virus type 1 (HIV-1) infected patients and are not replenished even after successful combined antiretroviral therapy (cART). This study aimed to identify the mechanism underlying MAIT...

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Bibliographic Details
Main Authors: Peng Xia, Xu-Dong Xing, Cui-Xian Yang, Xue-Jiao Liao, Fu-Hua Liu, Hui-Huang Huang, Chao Zhang, Jin-Wen Song, Yan-Mei Jiao, Ming Shi, Tian-Jun Jiang, Chun-Bao Zhou, Xi-Cheng Wang, Qing He, Qing-Lei Zeng, Fu-Sheng Wang, Ji-Yuan Zhang
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Military Medical Research
Subjects:
Acquired immune deficiency syndrome
Human immunodeficiency virus
Mucosal-associated invariant T cells
Pyroptosis
Immune reconstitution
Online Access:https://doi.org/10.1186/s40779-022-00384-1

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