Postnatal Involution and Counter-Involution of the Thymus
Thymus involution occurs in all vertebrates. It is thought to impact on immune responses in the aged, and in other clinical circumstances such as bone marrow transplantation. Determinants of thymus growth and size are beginning to be identified. Ectopic expression of factors like cyclin D1 and Myc i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.00897/full |
| _version_ | 1828348307578028032 |
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| author | Jennifer E. Cowan Yousuke Takahama Avinash Bhandoola Izumi Ohigashi |
| author_facet | Jennifer E. Cowan Yousuke Takahama Avinash Bhandoola Izumi Ohigashi |
| author_sort | Jennifer E. Cowan |
| collection | DOAJ |
| description | Thymus involution occurs in all vertebrates. It is thought to impact on immune responses in the aged, and in other clinical circumstances such as bone marrow transplantation. Determinants of thymus growth and size are beginning to be identified. Ectopic expression of factors like cyclin D1 and Myc in thymic epithelial cells (TEC)s results in considerable increase in thymus size. These models provide useful experimental tools that allow thymus function to be understood. In future, understanding TEC-specific controllers of growth will provide new approaches to thymus regeneration. |
| first_indexed | 2024-04-14T00:52:04Z |
| format | Article |
| id | doaj.art-c993fea9a7bb4a5ead83c786d4468663 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-14T00:52:04Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-c993fea9a7bb4a5ead83c786d44686632022-12-22T02:21:45ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-05-011110.3389/fimmu.2020.00897536686Postnatal Involution and Counter-Involution of the ThymusJennifer E. Cowan0Yousuke Takahama1Avinash Bhandoola2Izumi Ohigashi3Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United StatesExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United StatesLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United StatesDivision of Experimental Immunology, Institute of Advanced Medical Sciences, University of Tokushima, Tokushima, JapanThymus involution occurs in all vertebrates. It is thought to impact on immune responses in the aged, and in other clinical circumstances such as bone marrow transplantation. Determinants of thymus growth and size are beginning to be identified. Ectopic expression of factors like cyclin D1 and Myc in thymic epithelial cells (TEC)s results in considerable increase in thymus size. These models provide useful experimental tools that allow thymus function to be understood. In future, understanding TEC-specific controllers of growth will provide new approaches to thymus regeneration.https://www.frontiersin.org/article/10.3389/fimmu.2020.00897/fullthymusMyccyclin D1growthinvolutionaging |
| spellingShingle | Jennifer E. Cowan Yousuke Takahama Avinash Bhandoola Izumi Ohigashi Postnatal Involution and Counter-Involution of the Thymus Frontiers in Immunology thymus Myc cyclin D1 growth involution aging |
| title | Postnatal Involution and Counter-Involution of the Thymus |
| title_full | Postnatal Involution and Counter-Involution of the Thymus |
| title_fullStr | Postnatal Involution and Counter-Involution of the Thymus |
| title_full_unstemmed | Postnatal Involution and Counter-Involution of the Thymus |
| title_short | Postnatal Involution and Counter-Involution of the Thymus |
| title_sort | postnatal involution and counter involution of the thymus |
| topic | thymus Myc cyclin D1 growth involution aging |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.00897/full |
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