The Effects of Hydroalcoholic Extract of Dracocephalum Kotschyi on Biochemical Blood Parameters in Diabetic Male Rats
Background: Diabetes mellitus is one of the most common endocrine diseases that impair the function of other body systems. This study conducted to determine the effect of hydro-alcoholic extract of Dracocephalum kotschyi on biochemical blood parameters of diabetic rats. Methods: In this experimenta...
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Isfahan University of Medical Sciences
2016-06-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/6153 |
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| author | Hamdollah Delaviz Majid Eskandari Nasrin Mohammadi Bahram Mohammadi Jamshid Mohammadi |
| author_facet | Hamdollah Delaviz Majid Eskandari Nasrin Mohammadi Bahram Mohammadi Jamshid Mohammadi |
| author_sort | Hamdollah Delaviz |
| collection | DOAJ |
| description | Background: Diabetes mellitus is one of the most common endocrine diseases that impair the function of other body systems. This study conducted to determine the effect of hydro-alcoholic extract of Dracocephalum kotschyi on biochemical blood parameters of diabetic rats.
Methods: In this experimental study, 48 male Wistar rats (215 ± 35 g) randomly were divided into 6 equal groups. Normal control and diabetic control groups received distilled water, and the control group receivedhydroalcoholic extract of Dracocephalum kotschyi (120 mg/Kg). Three treatment diabetic groups received 40, 80 and 120 mg/Kg of a hydroalcoholic extract of Dracocephalum kotschyi respectively. All groups were treated orally by gavage which continued for 21 days. The level of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), albumin, creatinine and urea nitrogen in blood was measured at the end of the study in different groups.
Findings: The Mean blood glucose in the treatment groups with extract of Dracocephalum kotschyi decreased significantly compared to the diabetic control (P < 0.05). The mean of AST, ALT and ALP was significantly reduced in treating diabetic groups in comparison to the diabetic control (P < 0.05). The mean of albumin and urea nitrogen in the treatment groups with 80 and 120 mg/Kg of the extract were reduced significantly compared to the diabetic control (P < 0.05).
Conclusion: The dosage of 80 and 120 mg/Kg extract of Dracocephalum kotschyi improve liver and kidney function in diabetic rat. |
| first_indexed | 2024-03-12T09:12:10Z |
| format | Article |
| id | doaj.art-c9949752e0a14ede85506d034374c143 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T09:12:10Z |
| publishDate | 2016-06-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-c9949752e0a14ede85506d034374c1432023-09-02T14:57:54ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2016-06-01343794014072209The Effects of Hydroalcoholic Extract of Dracocephalum Kotschyi on Biochemical Blood Parameters in Diabetic Male RatsHamdollah Delaviz0Majid Eskandari1Nasrin Mohammadi2Bahram Mohammadi3Jamshid Mohammadi4Associate Professor, Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, IranDepartment of Physiology, School of Basic Sciences, Islamic Azad University, Fars Science and Research Branch, Shiraz, IranAssistant Professor, Department of Pediatrics, School of Medicine, Yasuj University of Medical Sciences, Yasuj, IranStudent of Medicine, School of Medicine, Yasuj University of Medical Sciences, Yasuj, IranAssociate Professor, Medicinal Plants Research Center AND Department of Physiology, School of Medicine, Yasuj University of Medical Sciences, Yasuj, IranBackground: Diabetes mellitus is one of the most common endocrine diseases that impair the function of other body systems. This study conducted to determine the effect of hydro-alcoholic extract of Dracocephalum kotschyi on biochemical blood parameters of diabetic rats. Methods: In this experimental study, 48 male Wistar rats (215 ± 35 g) randomly were divided into 6 equal groups. Normal control and diabetic control groups received distilled water, and the control group receivedhydroalcoholic extract of Dracocephalum kotschyi (120 mg/Kg). Three treatment diabetic groups received 40, 80 and 120 mg/Kg of a hydroalcoholic extract of Dracocephalum kotschyi respectively. All groups were treated orally by gavage which continued for 21 days. The level of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), albumin, creatinine and urea nitrogen in blood was measured at the end of the study in different groups. Findings: The Mean blood glucose in the treatment groups with extract of Dracocephalum kotschyi decreased significantly compared to the diabetic control (P < 0.05). The mean of AST, ALT and ALP was significantly reduced in treating diabetic groups in comparison to the diabetic control (P < 0.05). The mean of albumin and urea nitrogen in the treatment groups with 80 and 120 mg/Kg of the extract were reduced significantly compared to the diabetic control (P < 0.05). Conclusion: The dosage of 80 and 120 mg/Kg extract of Dracocephalum kotschyi improve liver and kidney function in diabetic rat.http://jims.mui.ac.ir/index.php/jims/article/view/6153Diabetes mellitusDracocephalum kotschyiLiver enzymesKidneyRat |
| spellingShingle | Hamdollah Delaviz Majid Eskandari Nasrin Mohammadi Bahram Mohammadi Jamshid Mohammadi The Effects of Hydroalcoholic Extract of Dracocephalum Kotschyi on Biochemical Blood Parameters in Diabetic Male Rats مجله دانشکده پزشکی اصفهان Diabetes mellitus Dracocephalum kotschyi Liver enzymes Kidney Rat |
| title | The Effects of Hydroalcoholic Extract of Dracocephalum Kotschyi on Biochemical Blood Parameters in Diabetic Male Rats |
| title_full | The Effects of Hydroalcoholic Extract of Dracocephalum Kotschyi on Biochemical Blood Parameters in Diabetic Male Rats |
| title_fullStr | The Effects of Hydroalcoholic Extract of Dracocephalum Kotschyi on Biochemical Blood Parameters in Diabetic Male Rats |
| title_full_unstemmed | The Effects of Hydroalcoholic Extract of Dracocephalum Kotschyi on Biochemical Blood Parameters in Diabetic Male Rats |
| title_short | The Effects of Hydroalcoholic Extract of Dracocephalum Kotschyi on Biochemical Blood Parameters in Diabetic Male Rats |
| title_sort | effects of hydroalcoholic extract of dracocephalum kotschyi on biochemical blood parameters in diabetic male rats |
| topic | Diabetes mellitus Dracocephalum kotschyi Liver enzymes Kidney Rat |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/6153 |
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