Sleep Deprivation and Central Appetite Regulation
Research shows that reduced sleep duration is related to an increased risk of obesity. The relationship between sleep deprivation and obesity, type 2 diabetes, and other chronic diseases may be related to the imbalance of appetite regulation. To comprehensively illustrate the specific relationship b...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
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| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/14/24/5196 |
| _version_ | 1797455964913270784 |
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| author | Shuailing Liu Xiya Wang Qian Zheng Lanyue Gao Qi Sun |
| author_facet | Shuailing Liu Xiya Wang Qian Zheng Lanyue Gao Qi Sun |
| author_sort | Shuailing Liu |
| collection | DOAJ |
| description | Research shows that reduced sleep duration is related to an increased risk of obesity. The relationship between sleep deprivation and obesity, type 2 diabetes, and other chronic diseases may be related to the imbalance of appetite regulation. To comprehensively illustrate the specific relationship between sleep deprivation and appetite regulation, this review introduces the pathophysiology of sleep deprivation, the research cutting edge of animal models, and the central regulatory mechanism of appetite under sleep deprivation. This paper summarizes the changes in appetite-related hormones orexin, ghrelin, leptin, and insulin secretion caused by long-term sleep deprivation based on the epidemiology data and animal studies that have established sleep deprivation models. Moreover, this review analyzes the potential mechanism of associations between appetite regulation and sleep deprivation, providing more clues on further studies and new strategies to access obesity and metabolic disease. |
| first_indexed | 2024-03-09T16:00:42Z |
| format | Article |
| id | doaj.art-c9973f0b30c1494f92e0f07171ca01b4 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T16:00:42Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-c9973f0b30c1494f92e0f07171ca01b42023-11-24T17:07:09ZengMDPI AGNutrients2072-66432022-12-011424519610.3390/nu14245196Sleep Deprivation and Central Appetite RegulationShuailing Liu0Xiya Wang1Qian Zheng2Lanyue Gao3Qi Sun4Department of Child and Adolescent Health, School of Public Health, China Medical University, Shenyang 110122, ChinaDepartment of Child and Adolescent Health, School of Public Health, China Medical University, Shenyang 110122, ChinaDepartment of Child and Adolescent Health, School of Public Health, China Medical University, Shenyang 110122, ChinaExperimental Center for School of Public Health, China Medical University, Shenyang 110122, ChinaDepartment of Child and Adolescent Health, School of Public Health, China Medical University, Shenyang 110122, ChinaResearch shows that reduced sleep duration is related to an increased risk of obesity. The relationship between sleep deprivation and obesity, type 2 diabetes, and other chronic diseases may be related to the imbalance of appetite regulation. To comprehensively illustrate the specific relationship between sleep deprivation and appetite regulation, this review introduces the pathophysiology of sleep deprivation, the research cutting edge of animal models, and the central regulatory mechanism of appetite under sleep deprivation. This paper summarizes the changes in appetite-related hormones orexin, ghrelin, leptin, and insulin secretion caused by long-term sleep deprivation based on the epidemiology data and animal studies that have established sleep deprivation models. Moreover, this review analyzes the potential mechanism of associations between appetite regulation and sleep deprivation, providing more clues on further studies and new strategies to access obesity and metabolic disease.https://www.mdpi.com/2072-6643/14/24/5196sleep deprivationcentral appetiteanimal modelscircadianchildhood obesity |
| spellingShingle | Shuailing Liu Xiya Wang Qian Zheng Lanyue Gao Qi Sun Sleep Deprivation and Central Appetite Regulation Nutrients sleep deprivation central appetite animal models circadian childhood obesity |
| title | Sleep Deprivation and Central Appetite Regulation |
| title_full | Sleep Deprivation and Central Appetite Regulation |
| title_fullStr | Sleep Deprivation and Central Appetite Regulation |
| title_full_unstemmed | Sleep Deprivation and Central Appetite Regulation |
| title_short | Sleep Deprivation and Central Appetite Regulation |
| title_sort | sleep deprivation and central appetite regulation |
| topic | sleep deprivation central appetite animal models circadian childhood obesity |
| url | https://www.mdpi.com/2072-6643/14/24/5196 |
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