Transient Lactic Acidosis and Elevation of Transaminases after the Introduction of Remdesivir in a Patient with Acute Kidney Injury
A 56-year-old woman was transferred to the intensive care unit (ICU) two days after an allogeneic stem cell transplantation (ASCT) when she presented acute respiratory distress due to the relapse of a SARS-CoV-2 infection. Following that, she received two intravenous doses of 100 mg remdesivir. Subs...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2024-01-01
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| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2024/6631866 |
| _version_ | 1797289897013280768 |
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| author | Elise André Florian Lemaitre Marie-Clémence Verdier Vincent Haufroid João Pinto Pereira Philippe Hantson |
| author_facet | Elise André Florian Lemaitre Marie-Clémence Verdier Vincent Haufroid João Pinto Pereira Philippe Hantson |
| author_sort | Elise André |
| collection | DOAJ |
| description | A 56-year-old woman was transferred to the intensive care unit (ICU) two days after an allogeneic stem cell transplantation (ASCT) when she presented acute respiratory distress due to the relapse of a SARS-CoV-2 infection. Following that, she received two intravenous doses of 100 mg remdesivir. Subsequently, the patient developed multiple instances of diarrhea, progressing to oliguria and acute kidney injury, necessitating continuous venovenous hemofiltration (CVVH). Despite the absence of signs of hypoxemia or cardiocirculatory failure requiring vasopressor intervention, a progressive lactic acidosis emerged. Two days after the onset of lactic acidosis, a significant rise in aminotransferases and lactate dehydrogenase occurred, in the absence of encephalopathy and coagulation disorders. Remdesivir therapy had been interrupted upon the initial signs of lactic acidosis. Despite an improvement in liver function tests and lactic acidosis, the patient’s condition deteriorated, ultimately leading to her demise on day 29 due to newly arising hematological complications. |
| first_indexed | 2024-03-07T19:12:39Z |
| format | Article |
| id | doaj.art-c999a74c40c541cb9f129d001f05d242 |
| institution | Directory Open Access Journal |
| issn | 2090-6439 |
| language | English |
| last_indexed | 2024-03-07T19:12:39Z |
| publishDate | 2024-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj.art-c999a74c40c541cb9f129d001f05d2422024-03-01T00:00:00ZengHindawi LimitedCase Reports in Critical Care2090-64392024-01-01202410.1155/2024/6631866Transient Lactic Acidosis and Elevation of Transaminases after the Introduction of Remdesivir in a Patient with Acute Kidney InjuryElise André0Florian Lemaitre1Marie-Clémence Verdier2Vincent Haufroid3João Pinto Pereira4Philippe Hantson5Department of Intensive CareUniv RennesUniv RennesClinical Chemistry DepartmentDepartment of Intensive CareDepartment of Intensive CareA 56-year-old woman was transferred to the intensive care unit (ICU) two days after an allogeneic stem cell transplantation (ASCT) when she presented acute respiratory distress due to the relapse of a SARS-CoV-2 infection. Following that, she received two intravenous doses of 100 mg remdesivir. Subsequently, the patient developed multiple instances of diarrhea, progressing to oliguria and acute kidney injury, necessitating continuous venovenous hemofiltration (CVVH). Despite the absence of signs of hypoxemia or cardiocirculatory failure requiring vasopressor intervention, a progressive lactic acidosis emerged. Two days after the onset of lactic acidosis, a significant rise in aminotransferases and lactate dehydrogenase occurred, in the absence of encephalopathy and coagulation disorders. Remdesivir therapy had been interrupted upon the initial signs of lactic acidosis. Despite an improvement in liver function tests and lactic acidosis, the patient’s condition deteriorated, ultimately leading to her demise on day 29 due to newly arising hematological complications.http://dx.doi.org/10.1155/2024/6631866 |
| spellingShingle | Elise André Florian Lemaitre Marie-Clémence Verdier Vincent Haufroid João Pinto Pereira Philippe Hantson Transient Lactic Acidosis and Elevation of Transaminases after the Introduction of Remdesivir in a Patient with Acute Kidney Injury Case Reports in Critical Care |
| title | Transient Lactic Acidosis and Elevation of Transaminases after the Introduction of Remdesivir in a Patient with Acute Kidney Injury |
| title_full | Transient Lactic Acidosis and Elevation of Transaminases after the Introduction of Remdesivir in a Patient with Acute Kidney Injury |
| title_fullStr | Transient Lactic Acidosis and Elevation of Transaminases after the Introduction of Remdesivir in a Patient with Acute Kidney Injury |
| title_full_unstemmed | Transient Lactic Acidosis and Elevation of Transaminases after the Introduction of Remdesivir in a Patient with Acute Kidney Injury |
| title_short | Transient Lactic Acidosis and Elevation of Transaminases after the Introduction of Remdesivir in a Patient with Acute Kidney Injury |
| title_sort | transient lactic acidosis and elevation of transaminases after the introduction of remdesivir in a patient with acute kidney injury |
| url | http://dx.doi.org/10.1155/2024/6631866 |
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