Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy
Abstract Targeted therapies, such as endocrine therapies (ET), can exert selective pressure on cancer cells and promote adaptations that confer treatment resistance. In this study, we show that ET resistance in breast cancer drives radiation resistance through reprogramming of DNA repair pathways. W...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | npj Precision Oncology |
| Online Access: | https://doi.org/10.1038/s41698-023-00348-1 |
| _version_ | 1797641434325581824 |
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| author | S. M. Nashir Udden GuemHee Baek Kamal Pandey Chantal Vidal Yulun Liu Asal S. Rahimi D. Nathan Kim Chika R. Nwachukwu Ram S. Mani Prasanna G. Alluri |
| author_facet | S. M. Nashir Udden GuemHee Baek Kamal Pandey Chantal Vidal Yulun Liu Asal S. Rahimi D. Nathan Kim Chika R. Nwachukwu Ram S. Mani Prasanna G. Alluri |
| author_sort | S. M. Nashir Udden |
| collection | DOAJ |
| description | Abstract Targeted therapies, such as endocrine therapies (ET), can exert selective pressure on cancer cells and promote adaptations that confer treatment resistance. In this study, we show that ET resistance in breast cancer drives radiation resistance through reprogramming of DNA repair pathways. We also show that pharmacological bromodomain and extraterminal domain inhibition reverses pathological DNA repair reprogramming in ET-resistant breast tumors and overcomes resistance to radiation therapy. |
| first_indexed | 2024-03-11T13:45:36Z |
| format | Article |
| id | doaj.art-c99af9910d324a5f889bbd6bf2d4236c |
| institution | Directory Open Access Journal |
| issn | 2397-768X |
| language | English |
| last_indexed | 2024-03-11T13:45:36Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Precision Oncology |
| spelling | doaj.art-c99af9910d324a5f889bbd6bf2d4236c2023-11-02T10:37:50ZengNature Portfolionpj Precision Oncology2397-768X2023-01-01711810.1038/s41698-023-00348-1Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapyS. M. Nashir Udden0GuemHee Baek1Kamal Pandey2Chantal Vidal3Yulun Liu4Asal S. Rahimi5D. Nathan Kim6Chika R. Nwachukwu7Ram S. Mani8Prasanna G. Alluri9Department of Radiation Oncology, UT Southwestern Medical CenterDepartment of Pathology, UT Southwestern Medical CenterDepartment of Radiation Oncology, UT Southwestern Medical CenterDepartment of Radiation Oncology, UT Southwestern Medical CenterHarold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical CenterDepartment of Radiation Oncology, UT Southwestern Medical CenterDepartment of Radiation Oncology, UT Southwestern Medical CenterDepartment of Radiation Oncology, UT Southwestern Medical CenterDepartment of Pathology, UT Southwestern Medical CenterDepartment of Radiation Oncology, UT Southwestern Medical CenterAbstract Targeted therapies, such as endocrine therapies (ET), can exert selective pressure on cancer cells and promote adaptations that confer treatment resistance. In this study, we show that ET resistance in breast cancer drives radiation resistance through reprogramming of DNA repair pathways. We also show that pharmacological bromodomain and extraterminal domain inhibition reverses pathological DNA repair reprogramming in ET-resistant breast tumors and overcomes resistance to radiation therapy.https://doi.org/10.1038/s41698-023-00348-1 |
| spellingShingle | S. M. Nashir Udden GuemHee Baek Kamal Pandey Chantal Vidal Yulun Liu Asal S. Rahimi D. Nathan Kim Chika R. Nwachukwu Ram S. Mani Prasanna G. Alluri Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy npj Precision Oncology |
| title | Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy |
| title_full | Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy |
| title_fullStr | Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy |
| title_full_unstemmed | Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy |
| title_short | Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy |
| title_sort | towards precision radiation oncology endocrine therapy response as a biomarker for personalization of breast radiotherapy |
| url | https://doi.org/10.1038/s41698-023-00348-1 |
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