The role of IL-33/ST2 system in the modulation of the immune response in infective endocarditis (a literature review)
An inflammatory process accompanied by a considerable number of pathological conditions in the body is one of the symptoms of infective endocarditis. The components of the immune system involved in the inflammatory response may serve as markers determining the development and prognosis of the diseas...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2020-07-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/2869 |
| _version_ | 1797872850090065920 |
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| author | M. A. Asanov A. V. Ponasenko |
| author_facet | M. A. Asanov A. V. Ponasenko |
| author_sort | M. A. Asanov |
| collection | DOAJ |
| description | An inflammatory process accompanied by a considerable number of pathological conditions in the body is one of the symptoms of infective endocarditis. The components of the immune system involved in the inflammatory response may serve as markers determining the development and prognosis of the disease and as potential therapeutic targets. These components include cytokines IL-33, sST2, and the IL-33/ST2 system, which are actively involved in the modulation of the inflammatory response. At present, the role of these biologically active molecules is well described for various pathologies associated with tissue destruction, including cardiovascular diseases, but not for the pathogenesis of infective endocarditis. This review is aimed at analyzing the available information on the pathogenesis of infective endocarditis, the role of IL-33 and ST2 in the formation of the inflammatory response in various pathological processes, and changes in the expression of the genes encoding these proteins under the influence of various factors. |
| first_indexed | 2024-04-10T01:05:39Z |
| format | Article |
| id | doaj.art-c99d10ecb0f547c096ca9143569691eb |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:05:39Z |
| publishDate | 2020-07-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-c99d10ecb0f547c096ca9143569691eb2023-03-13T09:58:26ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842020-07-0119212013110.20538/1682-0363-2020-2-120-1311629The role of IL-33/ST2 system in the modulation of the immune response in infective endocarditis (a literature review)M. A. Asanov0A. V. Ponasenko1Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний (НИИ КПССЗ); Федеральный исследовательский центр угля и углехимии СО РАН (ФИЦ УУХ СО РАН)Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний (НИИ КПССЗ)An inflammatory process accompanied by a considerable number of pathological conditions in the body is one of the symptoms of infective endocarditis. The components of the immune system involved in the inflammatory response may serve as markers determining the development and prognosis of the disease and as potential therapeutic targets. These components include cytokines IL-33, sST2, and the IL-33/ST2 system, which are actively involved in the modulation of the inflammatory response. At present, the role of these biologically active molecules is well described for various pathologies associated with tissue destruction, including cardiovascular diseases, but not for the pathogenesis of infective endocarditis. This review is aimed at analyzing the available information on the pathogenesis of infective endocarditis, the role of IL-33 and ST2 in the formation of the inflammatory response in various pathological processes, and changes in the expression of the genes encoding these proteins under the influence of various factors.https://bulletin.ssmu.ru/jour/article/view/2869il-33st2интерлейкининфекционный эндокардитсердечно-сосудистые заболеваниясекреция белкаэкспрессия гена |
| spellingShingle | M. A. Asanov A. V. Ponasenko The role of IL-33/ST2 system in the modulation of the immune response in infective endocarditis (a literature review) Бюллетень сибирской медицины il-33 st2 интерлейкин инфекционный эндокардит сердечно-сосудистые заболевания секреция белка экспрессия гена |
| title | The role of IL-33/ST2 system in the modulation of the immune response in infective endocarditis (a literature review) |
| title_full | The role of IL-33/ST2 system in the modulation of the immune response in infective endocarditis (a literature review) |
| title_fullStr | The role of IL-33/ST2 system in the modulation of the immune response in infective endocarditis (a literature review) |
| title_full_unstemmed | The role of IL-33/ST2 system in the modulation of the immune response in infective endocarditis (a literature review) |
| title_short | The role of IL-33/ST2 system in the modulation of the immune response in infective endocarditis (a literature review) |
| title_sort | role of il 33 st2 system in the modulation of the immune response in infective endocarditis a literature review |
| topic | il-33 st2 интерлейкин инфекционный эндокардит сердечно-сосудистые заболевания секреция белка экспрессия гена |
| url | https://bulletin.ssmu.ru/jour/article/view/2869 |
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