Identification of a New Drug Binding Site in the RNA-Dependent-RNA-Polymerase (RdRp) Domain

Identification of a New Drug Binding Site in the RNA-Dependent-RNA-Polymerase (RdRp) Domain

We hypothesize that in silico structural biology approaches can discover novel drug binding sites for RNA-dependent-RNA-polymerases (RdRp) of positive sense single-strand RNA (ss(+)RNA) virus species. RdRps have a structurally conserved active site with seven motifs (A to G), despite low sequence si...

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Bibliographic Details
Main Authors: Aparna S. Gana, James N. Baraniuk
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:BioMedInformatics
Subjects:
RNA-dependent-RNA-polymerase (RdRp)
sirolimus
rapamycin
single-stranded positive-sense RNA viruses
ss(+)RNA
evolutionarily conserved region
Online Access:https://www.mdpi.com/2673-7426/3/4/55

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