Association of smoking with the survival of patients with brain metastasis of lung cancer
BackgroundSmoking is associated with increased mortality in patients with cancer. However, there are limited data on the impact of smoking on the survival of patients with brain metastases. Therefore, this study aimed to evaluate whether smoking was associated with survival and whether smoking cessa...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1036387/full |
| _version_ | 1797884439248764928 |
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| author | Jiayi Yu Jiayi Yu Yu Zhang Zheran Liu Yan He Yiyan Pei Renjie Zhang Xingchen Peng Fang Fang |
| author_facet | Jiayi Yu Jiayi Yu Yu Zhang Zheran Liu Yan He Yiyan Pei Renjie Zhang Xingchen Peng Fang Fang |
| author_sort | Jiayi Yu |
| collection | DOAJ |
| description | BackgroundSmoking is associated with increased mortality in patients with cancer. However, there are limited data on the impact of smoking on the survival of patients with brain metastases. Therefore, this study aimed to evaluate whether smoking was associated with survival and whether smoking cessation was beneficial to these patients.MethodsThis study used lung cancer with a brain metastasis cohort of the West China Hospital of Sichuan University from 2013 to 2021. Patients were stratified according to smoking history; the distribution, clinical characteristics, and survival data of each group were estimated. Kaplan-Meier analysis and risk analysis were performed for the survival endpoint.ResultsOf the 2,647 patients included in the analysis, the median age was 57.8 years, and 55.4% were men. Among them, 67.1% had no smoking history, 18.9% still smoked, and 14% reported quitting smoking. Compared with never smokers, current smokers [HR, 1.51 (95% CI, 1.35-1.69), p < 0.01] and former smokers [HR, 1.32 (95% CI, 1.16-1.49), p<0.01] had an increased risk of death. However, quitting smoking was not associated with improved survival [HR, 0.90 (95% CI, 0.77-1.04), p = 0.16]. The overall survival increased with the increase of smoking cessation years.ConclusionsIn lung cancer patients with brain metastases, smoking was associated with an increased risk of death, but quitting smoking was not associated with improved survival. |
| first_indexed | 2024-04-10T04:07:40Z |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T04:07:40Z |
| publishDate | 2023-03-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-c99e1b7b0b994284bb01e96364eddc002023-03-13T05:14:09ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-03-011410.3389/fneur.2023.10363871036387Association of smoking with the survival of patients with brain metastasis of lung cancerJiayi Yu0Jiayi Yu1Yu Zhang2Zheran Liu3Yan He4Yiyan Pei5Renjie Zhang6Xingchen Peng7Fang Fang8School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaDepartment of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Neurosurgery, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, ChinaDepartment of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, ChinaWest China Hospital, Sichuan University, Chengdu, Sichuan, ChinaBackgroundSmoking is associated with increased mortality in patients with cancer. However, there are limited data on the impact of smoking on the survival of patients with brain metastases. Therefore, this study aimed to evaluate whether smoking was associated with survival and whether smoking cessation was beneficial to these patients.MethodsThis study used lung cancer with a brain metastasis cohort of the West China Hospital of Sichuan University from 2013 to 2021. Patients were stratified according to smoking history; the distribution, clinical characteristics, and survival data of each group were estimated. Kaplan-Meier analysis and risk analysis were performed for the survival endpoint.ResultsOf the 2,647 patients included in the analysis, the median age was 57.8 years, and 55.4% were men. Among them, 67.1% had no smoking history, 18.9% still smoked, and 14% reported quitting smoking. Compared with never smokers, current smokers [HR, 1.51 (95% CI, 1.35-1.69), p < 0.01] and former smokers [HR, 1.32 (95% CI, 1.16-1.49), p<0.01] had an increased risk of death. However, quitting smoking was not associated with improved survival [HR, 0.90 (95% CI, 0.77-1.04), p = 0.16]. The overall survival increased with the increase of smoking cessation years.ConclusionsIn lung cancer patients with brain metastases, smoking was associated with an increased risk of death, but quitting smoking was not associated with improved survival.https://www.frontiersin.org/articles/10.3389/fneur.2023.1036387/fullsmokinglung cancerbrain metastasissmoking cessationthe overall survival |
| spellingShingle | Jiayi Yu Jiayi Yu Yu Zhang Zheran Liu Yan He Yiyan Pei Renjie Zhang Xingchen Peng Fang Fang Association of smoking with the survival of patients with brain metastasis of lung cancer Frontiers in Neurology smoking lung cancer brain metastasis smoking cessation the overall survival |
| title | Association of smoking with the survival of patients with brain metastasis of lung cancer |
| title_full | Association of smoking with the survival of patients with brain metastasis of lung cancer |
| title_fullStr | Association of smoking with the survival of patients with brain metastasis of lung cancer |
| title_full_unstemmed | Association of smoking with the survival of patients with brain metastasis of lung cancer |
| title_short | Association of smoking with the survival of patients with brain metastasis of lung cancer |
| title_sort | association of smoking with the survival of patients with brain metastasis of lung cancer |
| topic | smoking lung cancer brain metastasis smoking cessation the overall survival |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1036387/full |
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