Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity.

Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity.

Diabetes mellitus is associated with cognitive deficits and an increased risk of dementia, particularly in the elderly. These deficits and the corresponding neurophysiological structural and functional alterations are linked to both metabolic and vascular changes, related to chronic hyperglycaemia,...

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Bibliographic Details
Main Authors: Derek A Costello, Marc Claret, Hind Al-Qassab, Florian Plattner, Elaine E Irvine, Agharul I Choudhury, K Peter Giese, Dominic J Withers, Paola Pedarzani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3287998?pdf=render

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