Prospects for repurposing CNS drugs for cancer treatment
Drug repurposing is the idea of using an already approved drug for another disease or disorder away from its initial use. This new approach ensures the reduction in high cost required for developing a new drug in addition to the time consumed, especially in the tumor disorders that show an unceasing...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-04-01
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| Series: | Oncology Reviews |
| Subjects: | |
| Online Access: | https://www.oncologyreviews.org/index.php/or/article/view/411 |
| _version_ | 1828076038940262400 |
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| author | Mohamed Abdelaleem Hossam Ezzat Muhammed Osama Adel Megahed Waleed Alaa Ahmed Gaber Ayman Shafei Alaa Refaat |
| author_facet | Mohamed Abdelaleem Hossam Ezzat Muhammed Osama Adel Megahed Waleed Alaa Ahmed Gaber Ayman Shafei Alaa Refaat |
| author_sort | Mohamed Abdelaleem |
| collection | DOAJ |
| description | Drug repurposing is the idea of using an already approved drug for another disease or disorder away from its initial use. This new approach ensures the reduction in high cost required for developing a new drug in addition to the time consumed, especially in the tumor disorders that show an unceasing rising rate with an unmet success rate of new anticancer drugs. In our review, we will review the anti-cancer effect of some CNS drugs, including both therapeutic and preventive, by searching the literature for preclinical or clinical evidence for anticancer potential of central nervous system drugs over the last 8 years period (2010-2018) and including only evidence from Q1 journals as indicated by Scimago website (www.scimagojr.com). We concluded that Some Central Nervous system drugs show a great potential as anti-cancer in vitro, in vivo and clinical trials through different mechanisms and pathways in different types of cancer that reveal a promising evidence for the repurposing of CNS drugs for new indications. |
| first_indexed | 2024-04-11T02:08:48Z |
| format | Article |
| id | doaj.art-c9a1ea76191048d59c2d75aea8ae106c |
| institution | Directory Open Access Journal |
| issn | 1970-5557 1970-5565 |
| language | English |
| last_indexed | 2024-04-11T02:08:48Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Oncology Reviews |
| spelling | doaj.art-c9a1ea76191048d59c2d75aea8ae106c2023-01-03T02:37:01ZengFrontiers Media S.A.Oncology Reviews1970-55571970-55652019-04-0113110.4081/oncol.2019.411Prospects for repurposing CNS drugs for cancer treatmentMohamed Abdelaleem0Hossam Ezzat1Muhammed Osama2Adel Megahed3Waleed Alaa4Ahmed Gaber5Ayman Shafei6Alaa Refaat7Armed Forces College of Medicine (AFCM), CairoArmed Forces College of Medicine (AFCM), CairoArmed Forces College of Medicine (AFCM), CairoArmed Forces College of Medicine (AFCM), CairoArmed Forces College of Medicine (AFCM), CairoArmed Forces College of Medicine (AFCM), CairoArmed Forces College of Medicine (AFCM), CairoArmed Forces College of Medicine (AFCM), Cairo, Egypt; Research Center, Misr International University (MIU), Cairo, Egypt; Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, KobeDrug repurposing is the idea of using an already approved drug for another disease or disorder away from its initial use. This new approach ensures the reduction in high cost required for developing a new drug in addition to the time consumed, especially in the tumor disorders that show an unceasing rising rate with an unmet success rate of new anticancer drugs. In our review, we will review the anti-cancer effect of some CNS drugs, including both therapeutic and preventive, by searching the literature for preclinical or clinical evidence for anticancer potential of central nervous system drugs over the last 8 years period (2010-2018) and including only evidence from Q1 journals as indicated by Scimago website (www.scimagojr.com). We concluded that Some Central Nervous system drugs show a great potential as anti-cancer in vitro, in vivo and clinical trials through different mechanisms and pathways in different types of cancer that reveal a promising evidence for the repurposing of CNS drugs for new indications.https://www.oncologyreviews.org/index.php/or/article/view/411CNS drugcancerrepurposable drugsrepositioning. |
| spellingShingle | Mohamed Abdelaleem Hossam Ezzat Muhammed Osama Adel Megahed Waleed Alaa Ahmed Gaber Ayman Shafei Alaa Refaat Prospects for repurposing CNS drugs for cancer treatment Oncology Reviews CNS drug cancer repurposable drugs repositioning. |
| title | Prospects for repurposing CNS drugs for cancer treatment |
| title_full | Prospects for repurposing CNS drugs for cancer treatment |
| title_fullStr | Prospects for repurposing CNS drugs for cancer treatment |
| title_full_unstemmed | Prospects for repurposing CNS drugs for cancer treatment |
| title_short | Prospects for repurposing CNS drugs for cancer treatment |
| title_sort | prospects for repurposing cns drugs for cancer treatment |
| topic | CNS drug cancer repurposable drugs repositioning. |
| url | https://www.oncologyreviews.org/index.php/or/article/view/411 |
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