Relevance of aneuploidy for cancer therapies targeting the spindle assembly checkpoint and KIF18A

Relevance of aneuploidy for cancer therapies targeting the spindle assembly checkpoint and KIF18A

Aneuploidy, a common feature of cancer cells, results in increased sensitivity to the inhibition of the spindle assembly checkpoint (SAC) and the mitotic motor protein Kinesin Family Member 18A (KIF18A). We discuss the importance of drugs targeting SAC core members and KIF18A. We stress the need to...

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Bibliographic Details
Main Authors: Yael Cohen-Sharir, Uri Ben-David
Format: Article
Language:English
Published: Taylor & Francis Group 2021-05-01
Series:Molecular & Cellular Oncology
Subjects:
aneuploidy
cancer
spindle assembly checkpoint
sac
kif18a
cancer therapies
Online Access:http://dx.doi.org/10.1080/23723556.2021.1915075

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