Regulatory network characterization in development: challenges and opportunities [version 1; referees: 2 approved]
Embryonic development and stem cell differentiation, during which coordinated cell fate specification takes place in a spatial and temporal context, serve as a paradigm for studying the orderly assembly of gene regulatory networks (GRNs) and the fundamental mechanism of GRNs in driving lineage deter...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2018-09-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/7-1477/v1 |
| _version_ | 1828489514800119808 |
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| author | Guangdun Peng Jing-Dong J. Han |
| author_facet | Guangdun Peng Jing-Dong J. Han |
| author_sort | Guangdun Peng |
| collection | DOAJ |
| description | Embryonic development and stem cell differentiation, during which coordinated cell fate specification takes place in a spatial and temporal context, serve as a paradigm for studying the orderly assembly of gene regulatory networks (GRNs) and the fundamental mechanism of GRNs in driving lineage determination. However, knowledge of reliable GRN annotation for dynamic development regulation, particularly for unveiling the complex temporal and spatial architecture of tissue stem cells, remains inadequate. With the advent of single-cell RNA sequencing technology, elucidating GRNs in development and stem cell processes poses both new challenges and unprecedented opportunities. This review takes a snapshot of some of this work and its implication in the regulative nature of early mammalian development and specification of the distinct cell types during embryogenesis. |
| first_indexed | 2024-12-11T10:27:20Z |
| format | Article |
| id | doaj.art-c9a2cb9a36b2476f8197d8143de9d16c |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-11T10:27:20Z |
| publishDate | 2018-09-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-c9a2cb9a36b2476f8197d8143de9d16c2022-12-22T01:11:06ZengF1000 Research LtdF1000Research2046-14022018-09-01710.12688/f1000research.15271.116636Regulatory network characterization in development: challenges and opportunities [version 1; referees: 2 approved]Guangdun Peng0Jing-Dong J. Han1CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, ChinaKey Laboratory of Computational Biology, CAS Center for Excellence in Molecular Cell Science, Collaborative Innovation Center for Genetics and Developmental Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, ChinaEmbryonic development and stem cell differentiation, during which coordinated cell fate specification takes place in a spatial and temporal context, serve as a paradigm for studying the orderly assembly of gene regulatory networks (GRNs) and the fundamental mechanism of GRNs in driving lineage determination. However, knowledge of reliable GRN annotation for dynamic development regulation, particularly for unveiling the complex temporal and spatial architecture of tissue stem cells, remains inadequate. With the advent of single-cell RNA sequencing technology, elucidating GRNs in development and stem cell processes poses both new challenges and unprecedented opportunities. This review takes a snapshot of some of this work and its implication in the regulative nature of early mammalian development and specification of the distinct cell types during embryogenesis.https://f1000research.com/articles/7-1477/v1 |
| spellingShingle | Guangdun Peng Jing-Dong J. Han Regulatory network characterization in development: challenges and opportunities [version 1; referees: 2 approved] F1000Research |
| title | Regulatory network characterization in development: challenges and opportunities [version 1; referees: 2 approved] |
| title_full | Regulatory network characterization in development: challenges and opportunities [version 1; referees: 2 approved] |
| title_fullStr | Regulatory network characterization in development: challenges and opportunities [version 1; referees: 2 approved] |
| title_full_unstemmed | Regulatory network characterization in development: challenges and opportunities [version 1; referees: 2 approved] |
| title_short | Regulatory network characterization in development: challenges and opportunities [version 1; referees: 2 approved] |
| title_sort | regulatory network characterization in development challenges and opportunities version 1 referees 2 approved |
| url | https://f1000research.com/articles/7-1477/v1 |
| work_keys_str_mv | AT guangdunpeng regulatorynetworkcharacterizationindevelopmentchallengesandopportunitiesversion1referees2approved AT jingdongjhan regulatorynetworkcharacterizationindevelopmentchallengesandopportunitiesversion1referees2approved |