Intravitreal Injectable Hydrogels for Sustained Drug Delivery in Glaucoma Treatment and Therapy
Glaucoma is extensively treated with topical eye drops containing drugs. However, the retention time of the loaded drugs and the in vivo bioavailability of the drugs are highly influenced before reaching the targeted area sufficiently, due to physiological and anatomical barriers of the eye, such as...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/14/12/2359 |
| _version_ | 1797483091450658816 |
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| author | Kassahun Alula Akulo Terin Adali Mthabisi Talent George Moyo Tulin Bodamyali |
| author_facet | Kassahun Alula Akulo Terin Adali Mthabisi Talent George Moyo Tulin Bodamyali |
| author_sort | Kassahun Alula Akulo |
| collection | DOAJ |
| description | Glaucoma is extensively treated with topical eye drops containing drugs. However, the retention time of the loaded drugs and the in vivo bioavailability of the drugs are highly influenced before reaching the targeted area sufficiently, due to physiological and anatomical barriers of the eye, such as rapid nasolacrimal drainage. Poor intraocular penetration and frequent administration may also cause ocular cytotoxicity. A novel approach to overcome these drawbacks is the use of injectable hydrogels administered intravitreously for sustained drug delivery to the target site. These injectable hydrogels are used as nanocarriers to intimately interact with specific diseased ocular tissues to increase the therapeutic efficacy and drug bioavailability of the anti-glaucomic drugs. The human eye is very delicate, and is sensitive to contact with any foreign body material. However, natural biopolymers are non-reactive, biocompatible, biodegradable, and lack immunogenic and inflammatory responses to the host whenever they are incorporated in drug delivery systems. These favorable biomaterial properties have made them widely applicable in biomedical applications, with minimal adversity. This review highlights the importance of using natural biopolymer-based intravitreal hydrogel drug delivery systems for glaucoma treatment over conventional methods. |
| first_indexed | 2024-03-09T22:41:58Z |
| format | Article |
| id | doaj.art-c9a4d4d991e9445bb0265d180c1dc60f |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T22:41:58Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-c9a4d4d991e9445bb0265d180c1dc60f2023-11-23T18:36:37ZengMDPI AGPolymers2073-43602022-06-011412235910.3390/polym14122359Intravitreal Injectable Hydrogels for Sustained Drug Delivery in Glaucoma Treatment and TherapyKassahun Alula Akulo0Terin Adali1Mthabisi Talent George Moyo2Tulin Bodamyali3Department of Biomedical Engineering, Faculty of Engineering, Near East University, Mersin 10, Lefkoşa 99138, TurkeyDepartment of Biomedical Engineering, Faculty of Engineering, Near East University, Mersin 10, Lefkoşa 99138, TurkeyDepartment of Biomedical Engineering, Faculty of Engineering, Near East University, Mersin 10, Lefkoşa 99138, TurkeyDepartment of Pathology, Faculty of Medicine, Girne American University, Mersin 10, Girne 99428, TurkeyGlaucoma is extensively treated with topical eye drops containing drugs. However, the retention time of the loaded drugs and the in vivo bioavailability of the drugs are highly influenced before reaching the targeted area sufficiently, due to physiological and anatomical barriers of the eye, such as rapid nasolacrimal drainage. Poor intraocular penetration and frequent administration may also cause ocular cytotoxicity. A novel approach to overcome these drawbacks is the use of injectable hydrogels administered intravitreously for sustained drug delivery to the target site. These injectable hydrogels are used as nanocarriers to intimately interact with specific diseased ocular tissues to increase the therapeutic efficacy and drug bioavailability of the anti-glaucomic drugs. The human eye is very delicate, and is sensitive to contact with any foreign body material. However, natural biopolymers are non-reactive, biocompatible, biodegradable, and lack immunogenic and inflammatory responses to the host whenever they are incorporated in drug delivery systems. These favorable biomaterial properties have made them widely applicable in biomedical applications, with minimal adversity. This review highlights the importance of using natural biopolymer-based intravitreal hydrogel drug delivery systems for glaucoma treatment over conventional methods.https://www.mdpi.com/2073-4360/14/12/2359glaucomanatural biopolymersintravitreal injectable hydrogeldrug delivery systems |
| spellingShingle | Kassahun Alula Akulo Terin Adali Mthabisi Talent George Moyo Tulin Bodamyali Intravitreal Injectable Hydrogels for Sustained Drug Delivery in Glaucoma Treatment and Therapy Polymers glaucoma natural biopolymers intravitreal injectable hydrogel drug delivery systems |
| title | Intravitreal Injectable Hydrogels for Sustained Drug Delivery in Glaucoma Treatment and Therapy |
| title_full | Intravitreal Injectable Hydrogels for Sustained Drug Delivery in Glaucoma Treatment and Therapy |
| title_fullStr | Intravitreal Injectable Hydrogels for Sustained Drug Delivery in Glaucoma Treatment and Therapy |
| title_full_unstemmed | Intravitreal Injectable Hydrogels for Sustained Drug Delivery in Glaucoma Treatment and Therapy |
| title_short | Intravitreal Injectable Hydrogels for Sustained Drug Delivery in Glaucoma Treatment and Therapy |
| title_sort | intravitreal injectable hydrogels for sustained drug delivery in glaucoma treatment and therapy |
| topic | glaucoma natural biopolymers intravitreal injectable hydrogel drug delivery systems |
| url | https://www.mdpi.com/2073-4360/14/12/2359 |
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