Increased Receptor Affinity and Reduced Recognition by Specific Antibodies Contribute to Immune Escape of SARS-CoV-2 Variant Omicron

In this report, we mechanistically reveal how the Variant of Concern (VOC) SARS-CoV-2 Omicron (B.1.1.529) escapes neutralizing antibody responses, by physio-chemical characterization of this variant in comparison to the wild-type Wuhan and the Delta variant (B.1.617.2). Convalescent sera, as well as...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Anne-Cathrine S. Vogt, Gilles Augusto, Byron Martina, Xinyue Chang, Gheyath Nasrallah, Daniel E. Speiser, Monique Vogel, Martin F. Bachmann, Mona O. Mohsen
Format: Artikel
Sprache:English
Veröffentlicht: MDPI AG 2022-05-01
Schriftenreihe:Vaccines
Schlagworte:
Online Zugang:https://www.mdpi.com/2076-393X/10/5/743