The Signaling Pathways and Targets of Natural Compounds from Traditional Chinese Medicine in Treating Ischemic Stroke
Ischemic stroke (IS) is a common neurological disorder associated with high disability rates and mortality rates. At present, recombinant tissue plasminogen activator (r-tPA) is the only US(FDA)-approved drug for IS. However, due to the narrow therapeutic window and risk of intracerebral hemorrhage,...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/10/3099 |
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| author | Xing-Hua Li Feng-Ting Yin Xiao-Hang Zhou Ai-Hua Zhang Hui Sun Guang-Li Yan Xi-Jun Wang |
| author_facet | Xing-Hua Li Feng-Ting Yin Xiao-Hang Zhou Ai-Hua Zhang Hui Sun Guang-Li Yan Xi-Jun Wang |
| author_sort | Xing-Hua Li |
| collection | DOAJ |
| description | Ischemic stroke (IS) is a common neurological disorder associated with high disability rates and mortality rates. At present, recombinant tissue plasminogen activator (r-tPA) is the only US(FDA)-approved drug for IS. However, due to the narrow therapeutic window and risk of intracerebral hemorrhage, r-tPA is currently used in less than 5% of stroke patients. Natural compounds have been widely used in the treatment of IS in China and have a wide range of therapeutic effects on IS by regulating multiple targets and signaling pathways. The keywords “ischemia stroke, traditional Chinese Medicine, Chinese herbal medicine, natural compounds” were used to search the relevant literature in PubMed and other databases over the past five years. The results showed that JAK/STAT, NF-κB, MAPK, Notch, Nrf2, and PI3K/Akt are the key pathways, and SIRT1, MMP9, TLR4, HIF-α are the key targets for the natural compounds from traditional Chinese medicine in treating IS. This study aims to update and summarize the signaling pathways and targets of natural compounds in the treatment of IS, and provide a base of information for the future development of effective treatments for IS. |
| first_indexed | 2024-03-10T03:20:31Z |
| format | Article |
| id | doaj.art-c9a7c556646c4ef2b59dd7d9bbe38bdc |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:20:31Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c9a7c556646c4ef2b59dd7d9bbe38bdc2023-11-23T12:21:02ZengMDPI AGMolecules1420-30492022-05-012710309910.3390/molecules27103099The Signaling Pathways and Targets of Natural Compounds from Traditional Chinese Medicine in Treating Ischemic StrokeXing-Hua Li0Feng-Ting Yin1Xiao-Hang Zhou2Ai-Hua Zhang3Hui Sun4Guang-Li Yan5Xi-Jun Wang6National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaNational Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaNational Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaNational Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaNational Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaNational Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaNational Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaIschemic stroke (IS) is a common neurological disorder associated with high disability rates and mortality rates. At present, recombinant tissue plasminogen activator (r-tPA) is the only US(FDA)-approved drug for IS. However, due to the narrow therapeutic window and risk of intracerebral hemorrhage, r-tPA is currently used in less than 5% of stroke patients. Natural compounds have been widely used in the treatment of IS in China and have a wide range of therapeutic effects on IS by regulating multiple targets and signaling pathways. The keywords “ischemia stroke, traditional Chinese Medicine, Chinese herbal medicine, natural compounds” were used to search the relevant literature in PubMed and other databases over the past five years. The results showed that JAK/STAT, NF-κB, MAPK, Notch, Nrf2, and PI3K/Akt are the key pathways, and SIRT1, MMP9, TLR4, HIF-α are the key targets for the natural compounds from traditional Chinese medicine in treating IS. This study aims to update and summarize the signaling pathways and targets of natural compounds in the treatment of IS, and provide a base of information for the future development of effective treatments for IS.https://www.mdpi.com/1420-3049/27/10/3099ischemic strokenatural compoundstraditional Chinese medicinesignaling pathwaystargets |
| spellingShingle | Xing-Hua Li Feng-Ting Yin Xiao-Hang Zhou Ai-Hua Zhang Hui Sun Guang-Li Yan Xi-Jun Wang The Signaling Pathways and Targets of Natural Compounds from Traditional Chinese Medicine in Treating Ischemic Stroke Molecules ischemic stroke natural compounds traditional Chinese medicine signaling pathways targets |
| title | The Signaling Pathways and Targets of Natural Compounds from Traditional Chinese Medicine in Treating Ischemic Stroke |
| title_full | The Signaling Pathways and Targets of Natural Compounds from Traditional Chinese Medicine in Treating Ischemic Stroke |
| title_fullStr | The Signaling Pathways and Targets of Natural Compounds from Traditional Chinese Medicine in Treating Ischemic Stroke |
| title_full_unstemmed | The Signaling Pathways and Targets of Natural Compounds from Traditional Chinese Medicine in Treating Ischemic Stroke |
| title_short | The Signaling Pathways and Targets of Natural Compounds from Traditional Chinese Medicine in Treating Ischemic Stroke |
| title_sort | signaling pathways and targets of natural compounds from traditional chinese medicine in treating ischemic stroke |
| topic | ischemic stroke natural compounds traditional Chinese medicine signaling pathways targets |
| url | https://www.mdpi.com/1420-3049/27/10/3099 |
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