Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression

Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression

Immune responses to pancreatic ductal adenocarcinoma can be inhibited by cancer cells. Here the authors show that high levels of progranulin in PDAC inhibits immune responses by reducing MHC class I antigen presentation through enhanced degradation of MHC class I via autophagy.

Bibliographic Details
Main Authors: Phyllis F. Cheung, JiaJin Yang, Rui Fang, Arianna Borgers, Kirsten Krengel, Anne Stoffel, Kristina Althoff, Chi Wai Yip, Elaine H. L. Siu, Linda W. C. Ng, Karl S. Lang, Lamin B. Cham, Daniel R. Engel, Camille Soun, Igor Cima, Björn Scheffler, Jana K. Striefler, Marianne Sinn, Marcus Bahra, Uwe Pelzer, Helmut Oettle, Peter Markus, Esther M. M. Smeets, Erik H. J. G. Aarntzen, Konstantinos Savvatakis, Sven-Thorsten Liffers, Smiths S. Lueong, Christian Neander, Anna Bazarna, Xin Zhang, Annette Paschen, Howard C. Crawford, Anthony W. H. Chan, Siu Tim Cheung, Jens T. Siveke
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-27088-9
Description
Summary:Immune responses to pancreatic ductal adenocarcinoma can be inhibited by cancer cells. Here the authors show that high levels of progranulin in PDAC inhibits immune responses by reducing MHC class I antigen presentation through enhanced degradation of MHC class I via autophagy.
ISSN:2041-1723

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