Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression
Immune responses to pancreatic ductal adenocarcinoma can be inhibited by cancer cells. Here the authors show that high levels of progranulin in PDAC inhibits immune responses by reducing MHC class I antigen presentation through enhanced degradation of MHC class I via autophagy.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-27088-9 |
| _version_ | 1818753500657483776 |
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| author | Phyllis F. Cheung JiaJin Yang Rui Fang Arianna Borgers Kirsten Krengel Anne Stoffel Kristina Althoff Chi Wai Yip Elaine H. L. Siu Linda W. C. Ng Karl S. Lang Lamin B. Cham Daniel R. Engel Camille Soun Igor Cima Björn Scheffler Jana K. Striefler Marianne Sinn Marcus Bahra Uwe Pelzer Helmut Oettle Peter Markus Esther M. M. Smeets Erik H. J. G. Aarntzen Konstantinos Savvatakis Sven-Thorsten Liffers Smiths S. Lueong Christian Neander Anna Bazarna Xin Zhang Annette Paschen Howard C. Crawford Anthony W. H. Chan Siu Tim Cheung Jens T. Siveke |
| author_facet | Phyllis F. Cheung JiaJin Yang Rui Fang Arianna Borgers Kirsten Krengel Anne Stoffel Kristina Althoff Chi Wai Yip Elaine H. L. Siu Linda W. C. Ng Karl S. Lang Lamin B. Cham Daniel R. Engel Camille Soun Igor Cima Björn Scheffler Jana K. Striefler Marianne Sinn Marcus Bahra Uwe Pelzer Helmut Oettle Peter Markus Esther M. M. Smeets Erik H. J. G. Aarntzen Konstantinos Savvatakis Sven-Thorsten Liffers Smiths S. Lueong Christian Neander Anna Bazarna Xin Zhang Annette Paschen Howard C. Crawford Anthony W. H. Chan Siu Tim Cheung Jens T. Siveke |
| author_sort | Phyllis F. Cheung |
| collection | DOAJ |
| description | Immune responses to pancreatic ductal adenocarcinoma can be inhibited by cancer cells. Here the authors show that high levels of progranulin in PDAC inhibits immune responses by reducing MHC class I antigen presentation through enhanced degradation of MHC class I via autophagy. |
| first_indexed | 2024-12-18T05:08:21Z |
| format | Article |
| id | doaj.art-c9aa189db2194c2eba13f30f461a6fdd |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T05:08:21Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c9aa189db2194c2eba13f30f461a6fdd2022-12-21T21:19:57ZengNature PortfolioNature Communications2041-17232022-01-0113111810.1038/s41467-021-27088-9Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expressionPhyllis F. Cheung0JiaJin Yang1Rui Fang2Arianna Borgers3Kirsten Krengel4Anne Stoffel5Kristina Althoff6Chi Wai Yip7Elaine H. L. Siu8Linda W. C. Ng9Karl S. Lang10Lamin B. Cham11Daniel R. Engel12Camille Soun13Igor Cima14Björn Scheffler15Jana K. Striefler16Marianne Sinn17Marcus Bahra18Uwe Pelzer19Helmut Oettle20Peter Markus21Esther M. M. Smeets22Erik H. J. G. Aarntzen23Konstantinos Savvatakis24Sven-Thorsten Liffers25Smiths S. Lueong26Christian Neander27Anna Bazarna28Xin Zhang29Annette Paschen30Howard C. Crawford31Anthony W. H. Chan32Siu Tim Cheung33Jens T. Siveke34Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital EssenBridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital EssenBridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital EssenBridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital EssenBridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital EssenBridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital EssenBridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital EssenDepartment of Surgery, Prince of Wales Hospital, The Chinese University of Hong KongDepartment of Surgery, Prince of Wales Hospital, The Chinese University of Hong KongDepartment of Surgery, Prince of Wales Hospital, The Chinese University of Hong KongInstitute of Immunology, Medical Faculty, University of Duisburg-EssenInstitute of Immunology, Medical Faculty, University of Duisburg-EssenDepartment of Immunodynamics, Institute of Experimental Immunology and Imaging, University Hospital EssenDepartment of Immunodynamics, Institute of Experimental Immunology and Imaging, University Hospital EssenDKFZ-Division Translational Neurooncology at the WTZ, German Cancer Consortium (DKTK partner site Essen/Düsseldorf)DKFZ-Division Translational Neurooncology at the WTZ, German Cancer Consortium (DKTK partner site Essen/Düsseldorf)Universitätsmedizin Charité Berlin, CONKO Study Group, Department of Medical Oncology, Haematology and TumorimmunologyUniversitätsmedizin Charité Berlin, CONKO Study Group, Department of Medical Oncology, Haematology and TumorimmunologyDepartment of Surgical Oncology and Robotics, Krankenhaus WaldfriedeMedical Department, Division of Hematology, Oncology and Tumor Immunology, Charité University HospitalPraxis und TagesklinikDepartment of General, Visceral and Trauma Surgery, Elisabeth Hospital EssenDepartment of Medical Imaging, Radboud university medical CenterDepartment of Medical Imaging, Radboud university medical CenterBridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital EssenBridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital EssenBridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital EssenBridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital EssenBridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital EssenBridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital EssenDepartment of Dermatology, University Hospital Essen, University of Duisburg-EssenRogel Comprehensive Cancer Center, University of MichiganDepartment of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong KongDepartment of Surgery, Prince of Wales Hospital, The Chinese University of Hong KongBridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital EssenImmune responses to pancreatic ductal adenocarcinoma can be inhibited by cancer cells. Here the authors show that high levels of progranulin in PDAC inhibits immune responses by reducing MHC class I antigen presentation through enhanced degradation of MHC class I via autophagy.https://doi.org/10.1038/s41467-021-27088-9 |
| spellingShingle | Phyllis F. Cheung JiaJin Yang Rui Fang Arianna Borgers Kirsten Krengel Anne Stoffel Kristina Althoff Chi Wai Yip Elaine H. L. Siu Linda W. C. Ng Karl S. Lang Lamin B. Cham Daniel R. Engel Camille Soun Igor Cima Björn Scheffler Jana K. Striefler Marianne Sinn Marcus Bahra Uwe Pelzer Helmut Oettle Peter Markus Esther M. M. Smeets Erik H. J. G. Aarntzen Konstantinos Savvatakis Sven-Thorsten Liffers Smiths S. Lueong Christian Neander Anna Bazarna Xin Zhang Annette Paschen Howard C. Crawford Anthony W. H. Chan Siu Tim Cheung Jens T. Siveke Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression Nature Communications |
| title | Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression |
| title_full | Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression |
| title_fullStr | Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression |
| title_full_unstemmed | Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression |
| title_short | Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression |
| title_sort | progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of mhci expression |
| url | https://doi.org/10.1038/s41467-021-27088-9 |
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