Manson's schistosomiasis in the undernourished mouse: some recent findings
This paper deals with current knowledge of the interrelationships between Schistosoma infection and malnutrition. It emphasizes the relevance of these investigations in the face of dynamic and evolving changes occurring in population diets and changes in the epidemiological patterns of schistosomias...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2010-07-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400002 |
| _version_ | 1827840539372814336 |
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| author | Eridan M Coutinho Sheilla A de Oliveira Andréia F de Barros Fabiana L Silva Renata P Ramos |
| author_facet | Eridan M Coutinho Sheilla A de Oliveira Andréia F de Barros Fabiana L Silva Renata P Ramos |
| author_sort | Eridan M Coutinho |
| collection | DOAJ |
| description | This paper deals with current knowledge of the interrelationships between Schistosoma infection and malnutrition. It emphasizes the relevance of these investigations in the face of dynamic and evolving changes occurring in population diets and changes in the epidemiological patterns of schistosomiasis in endemic countries. The paper further discusses the basis for continuing the studies on this subject and the reasons why it represents a misunderstood association. This review also focuses on the cellular and humoral immune responses in the undernourished mouse model infected with Schistosoma mansoni, with updated information on the immune response in wild-type and iNOS knockout mice concerning soluble egg antigen specific antibodies and kinetics of IFN-γ, IL-4, IL-10 and IL-13 cytokines, in the chronic phase of Manson's schistosomiasis. There is indication that schistosome-infected undernourished mice are able to develop a humoral immune response, but antibody titres are much lower than in the control animals. Cytokine production (IFN-γ, IL-4, IL-10) is lower in the undernourished mice, but as infection progresses to the chronic phase its kinetics run an antagonistic course when compared to that of well-nourished animals. Marked variation in the secretion of IL-13 (a fibrogenic cytokine) could explain why undernourished mice do not develop liver "pipe-stem" fibrosis described in previous papers on well-nourished animals. |
| first_indexed | 2024-03-12T07:35:32Z |
| format | Article |
| id | doaj.art-c9ab4ccd9c5f424386bc3cf5c0a58572 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T07:35:32Z |
| publishDate | 2010-07-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-c9ab4ccd9c5f424386bc3cf5c0a585722023-09-02T21:32:48ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602010-07-01105435936610.1590/S0074-02762010000400002Manson's schistosomiasis in the undernourished mouse: some recent findingsEridan M CoutinhoSheilla A de OliveiraAndréia F de BarrosFabiana L SilvaRenata P RamosThis paper deals with current knowledge of the interrelationships between Schistosoma infection and malnutrition. It emphasizes the relevance of these investigations in the face of dynamic and evolving changes occurring in population diets and changes in the epidemiological patterns of schistosomiasis in endemic countries. The paper further discusses the basis for continuing the studies on this subject and the reasons why it represents a misunderstood association. This review also focuses on the cellular and humoral immune responses in the undernourished mouse model infected with Schistosoma mansoni, with updated information on the immune response in wild-type and iNOS knockout mice concerning soluble egg antigen specific antibodies and kinetics of IFN-γ, IL-4, IL-10 and IL-13 cytokines, in the chronic phase of Manson's schistosomiasis. There is indication that schistosome-infected undernourished mice are able to develop a humoral immune response, but antibody titres are much lower than in the control animals. Cytokine production (IFN-γ, IL-4, IL-10) is lower in the undernourished mice, but as infection progresses to the chronic phase its kinetics run an antagonistic course when compared to that of well-nourished animals. Marked variation in the secretion of IL-13 (a fibrogenic cytokine) could explain why undernourished mice do not develop liver "pipe-stem" fibrosis described in previous papers on well-nourished animals.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400002Schistosoma mansoniundernutritionimmunopathology |
| spellingShingle | Eridan M Coutinho Sheilla A de Oliveira Andréia F de Barros Fabiana L Silva Renata P Ramos Manson's schistosomiasis in the undernourished mouse: some recent findings Memorias do Instituto Oswaldo Cruz Schistosoma mansoni undernutrition immunopathology |
| title | Manson's schistosomiasis in the undernourished mouse: some recent findings |
| title_full | Manson's schistosomiasis in the undernourished mouse: some recent findings |
| title_fullStr | Manson's schistosomiasis in the undernourished mouse: some recent findings |
| title_full_unstemmed | Manson's schistosomiasis in the undernourished mouse: some recent findings |
| title_short | Manson's schistosomiasis in the undernourished mouse: some recent findings |
| title_sort | manson s schistosomiasis in the undernourished mouse some recent findings |
| topic | Schistosoma mansoni undernutrition immunopathology |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400002 |
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