Fibroblast Growth Factor 21 (FGF21) Administration Sex-Specifically Affects Blood Insulin Levels and Liver Steatosis in Obese <i>A<sup>y</sup></i> Mice

Fibroblast Growth Factor 21 (FGF21) Administration Sex-Specifically Affects Blood Insulin Levels and Liver Steatosis in Obese <i>A<sup>y</sup></i> Mice

FGF21 is a promising candidate for treating obesity, diabetes, and NAFLD; however, some of its pharmacological effects are sex-specific in mice with the <i>A<sup>y</sup></i> mutation that evokes melanocortin receptor 4 blockade, obesity, and hepatosteatosis. This suggests tha...

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Bibliographic Details
Main Authors: Elena Makarova, Antonina Kazantseva, Anastasia Dubinina, Elena Denisova, Tatiana Jakovleva, Natalia Balybina, Nataliya Bgatova, Konstantin Baranov, Nadezhda Bazhan
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
FGF21
<i>A<sup>y</sup></i> mice
obesity
liver steatosis
sex differences
gene expression
Online Access:https://www.mdpi.com/2073-4409/10/12/3440

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