The crosstalk between parenchymal cells and macrophages: A keeper of tissue homeostasis
Non-parenchymal cells (NPCs) and parenchymal cells (PCs) collectively perform tissue-specific functions. PCs play significant roles and continuously adjust the intrinsic functions and metabolism of organs. Tissue-resident macrophages (TRMs) are crucial members of native NPCs in tissues and are essen...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1050188/full |
| _version_ | 1828098247412940800 |
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| author | Yusi Chen Li Tang |
| author_facet | Yusi Chen Li Tang |
| author_sort | Yusi Chen |
| collection | DOAJ |
| description | Non-parenchymal cells (NPCs) and parenchymal cells (PCs) collectively perform tissue-specific functions. PCs play significant roles and continuously adjust the intrinsic functions and metabolism of organs. Tissue-resident macrophages (TRMs) are crucial members of native NPCs in tissues and are essential for immune defense, tissue repair and development, and homeostasis maintenance. As a plastic-phenotypic and prevalent cluster of NPCs, TRMs dynamically assist PCs in functioning by producing cytokines, inflammatory and anti-inflammatory signals, growth factors, and proteolytic enzymes. Furthermore, the PCs of tissues modulate the functional activity and polarization of TRMs. Dysregulation of the PC‐TRM crosstalk axis profoundly impacts many essential physiological functions, including synaptogenesis, gastrointestinal motility and secretion, cardiac pulsation, gas exchange, blood filtration, and metabolic homeostasis. This review focuses on the PC‐TRM crosstalk in mammalian vital tissues, along with their interactions with tissue homeostasis maintenance and disorders. Thus, this review highlights the fundamental biological significance of the regulatory network of PC‐TRM in tissue homeostasis. |
| first_indexed | 2024-04-11T07:59:30Z |
| format | Article |
| id | doaj.art-c9af2bb036484048aedf3f2f270d100f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T07:59:30Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-c9af2bb036484048aedf3f2f270d100f2022-12-22T04:35:48ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.10501881050188The crosstalk between parenchymal cells and macrophages: A keeper of tissue homeostasisYusi ChenLi TangNon-parenchymal cells (NPCs) and parenchymal cells (PCs) collectively perform tissue-specific functions. PCs play significant roles and continuously adjust the intrinsic functions and metabolism of organs. Tissue-resident macrophages (TRMs) are crucial members of native NPCs in tissues and are essential for immune defense, tissue repair and development, and homeostasis maintenance. As a plastic-phenotypic and prevalent cluster of NPCs, TRMs dynamically assist PCs in functioning by producing cytokines, inflammatory and anti-inflammatory signals, growth factors, and proteolytic enzymes. Furthermore, the PCs of tissues modulate the functional activity and polarization of TRMs. Dysregulation of the PC‐TRM crosstalk axis profoundly impacts many essential physiological functions, including synaptogenesis, gastrointestinal motility and secretion, cardiac pulsation, gas exchange, blood filtration, and metabolic homeostasis. This review focuses on the PC‐TRM crosstalk in mammalian vital tissues, along with their interactions with tissue homeostasis maintenance and disorders. Thus, this review highlights the fundamental biological significance of the regulatory network of PC‐TRM in tissue homeostasis.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1050188/fullparenchymal cellstissue-resident macrophagescellular crosstalktissue-specific functionmammaliantissue homeostasis |
| spellingShingle | Yusi Chen Li Tang The crosstalk between parenchymal cells and macrophages: A keeper of tissue homeostasis Frontiers in Immunology parenchymal cells tissue-resident macrophages cellular crosstalk tissue-specific function mammalian tissue homeostasis |
| title | The crosstalk between parenchymal cells and macrophages: A keeper of tissue homeostasis |
| title_full | The crosstalk between parenchymal cells and macrophages: A keeper of tissue homeostasis |
| title_fullStr | The crosstalk between parenchymal cells and macrophages: A keeper of tissue homeostasis |
| title_full_unstemmed | The crosstalk between parenchymal cells and macrophages: A keeper of tissue homeostasis |
| title_short | The crosstalk between parenchymal cells and macrophages: A keeper of tissue homeostasis |
| title_sort | crosstalk between parenchymal cells and macrophages a keeper of tissue homeostasis |
| topic | parenchymal cells tissue-resident macrophages cellular crosstalk tissue-specific function mammalian tissue homeostasis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1050188/full |
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