Modeling the aging of protein condensates
Protein condensates formed by liquid-liquid phase separation exhibit aging rheological properties and are considered under biological regulation and related to multiple diseases. In this work we provide a mesoscopic framework to describe the rheology of protein condensates. A phase transition from a...
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| Format: | Article |
| Language: | English |
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American Physical Society
2022-04-01
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| Series: | Physical Review Research |
| Online Access: | http://doi.org/10.1103/PhysRevResearch.4.L022012 |
| _version_ | 1797210817262780416 |
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| author | Jie Lin |
| author_facet | Jie Lin |
| author_sort | Jie Lin |
| collection | DOAJ |
| description | Protein condensates formed by liquid-liquid phase separation exhibit aging rheological properties and are considered under biological regulation and related to multiple diseases. In this work we provide a mesoscopic framework to describe the rheology of protein condensates. A phase transition from a nonaging phase to an aging phase occurs when the temperature is below a critical value. In the aging phase, we find that protein condensates behave as Maxwell fluids at all ages in the linear viscoelastic regime and the viscosities increase linearly over time. We also show that protein condensates are non-Newtonian fluids under a constant shear rate and the stress-strain curve exhibits a power-law scaling at large strain. Our theories are consistent with experimental observations and also make general predictions that are experimentally testable. |
| first_indexed | 2024-04-24T10:16:37Z |
| format | Article |
| id | doaj.art-c9afa1b81dee46f6b93b42dc3d568f4d |
| institution | Directory Open Access Journal |
| issn | 2643-1564 |
| language | English |
| last_indexed | 2024-04-24T10:16:37Z |
| publishDate | 2022-04-01 |
| publisher | American Physical Society |
| record_format | Article |
| series | Physical Review Research |
| spelling | doaj.art-c9afa1b81dee46f6b93b42dc3d568f4d2024-04-12T17:19:57ZengAmerican Physical SocietyPhysical Review Research2643-15642022-04-0142L02201210.1103/PhysRevResearch.4.L022012Modeling the aging of protein condensatesJie LinProtein condensates formed by liquid-liquid phase separation exhibit aging rheological properties and are considered under biological regulation and related to multiple diseases. In this work we provide a mesoscopic framework to describe the rheology of protein condensates. A phase transition from a nonaging phase to an aging phase occurs when the temperature is below a critical value. In the aging phase, we find that protein condensates behave as Maxwell fluids at all ages in the linear viscoelastic regime and the viscosities increase linearly over time. We also show that protein condensates are non-Newtonian fluids under a constant shear rate and the stress-strain curve exhibits a power-law scaling at large strain. Our theories are consistent with experimental observations and also make general predictions that are experimentally testable.http://doi.org/10.1103/PhysRevResearch.4.L022012 |
| spellingShingle | Jie Lin Modeling the aging of protein condensates Physical Review Research |
| title | Modeling the aging of protein condensates |
| title_full | Modeling the aging of protein condensates |
| title_fullStr | Modeling the aging of protein condensates |
| title_full_unstemmed | Modeling the aging of protein condensates |
| title_short | Modeling the aging of protein condensates |
| title_sort | modeling the aging of protein condensates |
| url | http://doi.org/10.1103/PhysRevResearch.4.L022012 |
| work_keys_str_mv | AT jielin modelingtheagingofproteincondensates |