Outcomes of neonates born through meconium-stained amniotic fluid pre and post 2015 NRP guideline implementation.
A shift in the Neonatal Resuscitation Program (NRP) guidelines occurred in 2015 from routine intubation and endotracheal suctioning of all meconium-stained non-vigorous infants towards less aggressive interventions based on response to initial resuscitation. This study aims to examine the impact of...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0289945 |
| _version_ | 1797739715174072320 |
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| author | Ashley L Saint-Fleur Héctor E Alcalá Shanthy Sridhar |
| author_facet | Ashley L Saint-Fleur Héctor E Alcalá Shanthy Sridhar |
| author_sort | Ashley L Saint-Fleur |
| collection | DOAJ |
| description | A shift in the Neonatal Resuscitation Program (NRP) guidelines occurred in 2015 from routine intubation and endotracheal suctioning of all meconium-stained non-vigorous infants towards less aggressive interventions based on response to initial resuscitation. This study aims to examine the impact of this change on outcomes of non-vigorous infants born through meconium-stained amniotic fluid at a level III academic NICU encompassing years before and after the change in guideline. This single-center retrospective study compared NICU therapies and clinical outcomes of 117 non-vigorous newborns pre-guideline implementation to 106 non-vigorous newborns post-guideline implementation. Nearly two thirds of infants in the pre-guideline cohort received endotracheal suctioning with recovery of meconium compared to less than a third of infants in the post-guideline cohort (p<0.01). Though a higher proportion of the pre-guideline cohort were admitted to the NICU for respiratory issues compared to the post-guideline cohort, the two groups did not differ significantly with regard to morbidity and therapies. Despite a marked reduction in rates of intubation and endotracheal suctioning, there is no difference in outcomes between pre-guideline implementation vs post-guideline implementation in non-vigorous meconium-stained infants, supporting the recent NRP guideline change and highlighting the benefit of expectant management. |
| first_indexed | 2024-03-12T14:01:10Z |
| format | Article |
| id | doaj.art-c9b022a1885a43298d98a40442e15cee |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-12T14:01:10Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c9b022a1885a43298d98a40442e15cee2023-08-22T05:31:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01188e028994510.1371/journal.pone.0289945Outcomes of neonates born through meconium-stained amniotic fluid pre and post 2015 NRP guideline implementation.Ashley L Saint-FleurHéctor E AlcaláShanthy SridharA shift in the Neonatal Resuscitation Program (NRP) guidelines occurred in 2015 from routine intubation and endotracheal suctioning of all meconium-stained non-vigorous infants towards less aggressive interventions based on response to initial resuscitation. This study aims to examine the impact of this change on outcomes of non-vigorous infants born through meconium-stained amniotic fluid at a level III academic NICU encompassing years before and after the change in guideline. This single-center retrospective study compared NICU therapies and clinical outcomes of 117 non-vigorous newborns pre-guideline implementation to 106 non-vigorous newborns post-guideline implementation. Nearly two thirds of infants in the pre-guideline cohort received endotracheal suctioning with recovery of meconium compared to less than a third of infants in the post-guideline cohort (p<0.01). Though a higher proportion of the pre-guideline cohort were admitted to the NICU for respiratory issues compared to the post-guideline cohort, the two groups did not differ significantly with regard to morbidity and therapies. Despite a marked reduction in rates of intubation and endotracheal suctioning, there is no difference in outcomes between pre-guideline implementation vs post-guideline implementation in non-vigorous meconium-stained infants, supporting the recent NRP guideline change and highlighting the benefit of expectant management.https://doi.org/10.1371/journal.pone.0289945 |
| spellingShingle | Ashley L Saint-Fleur Héctor E Alcalá Shanthy Sridhar Outcomes of neonates born through meconium-stained amniotic fluid pre and post 2015 NRP guideline implementation. PLoS ONE |
| title | Outcomes of neonates born through meconium-stained amniotic fluid pre and post 2015 NRP guideline implementation. |
| title_full | Outcomes of neonates born through meconium-stained amniotic fluid pre and post 2015 NRP guideline implementation. |
| title_fullStr | Outcomes of neonates born through meconium-stained amniotic fluid pre and post 2015 NRP guideline implementation. |
| title_full_unstemmed | Outcomes of neonates born through meconium-stained amniotic fluid pre and post 2015 NRP guideline implementation. |
| title_short | Outcomes of neonates born through meconium-stained amniotic fluid pre and post 2015 NRP guideline implementation. |
| title_sort | outcomes of neonates born through meconium stained amniotic fluid pre and post 2015 nrp guideline implementation |
| url | https://doi.org/10.1371/journal.pone.0289945 |
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