Craniocerebral involvement in lymphoma
Nine-hundred-eighty-nine patients with lymphoma were studied. Fifty-three cases (5.3%) had lymphomatous craniocerebral infiltration. The principal factors of risk for this complication were: advanced stage of the lymphoma (III or IV), diffuse histiocytic, diffuse poorly differentiated lymphocytic, o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
1990-09-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1990000300007&lng=en&tlng=en |
| _version_ | 1811232347514732544 |
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| author | Jorge D. Correale David A. Monteverde José A. Bueri Edgardo G. Reich Néstor Lucatelli |
| author_facet | Jorge D. Correale David A. Monteverde José A. Bueri Edgardo G. Reich Néstor Lucatelli |
| author_sort | Jorge D. Correale |
| collection | DOAJ |
| description | Nine-hundred-eighty-nine patients with lymphoma were studied. Fifty-three cases (5.3%) had lymphomatous craniocerebral infiltration. The principal factors of risk for this complication were: advanced stage of the lymphoma (III or IV), diffuse histiocytic, diffuse poorly differentiated lymphocytic, or mixed cellularity lymphoma histological type, bone marrow involvement, and previous systemic chemotherapy. Thirty-two per cent of the cases of meningeal lymphomatous infiltration were asymptomatic and represented autopsy findings. CT-scan was an useful test to detect brain focal parenchymatous infiltration, as opposed to meningeal infiltration. Mean survival time in patients with lymphomatous meningeal infiltration was 4.3 months, following the combined use of systemic chemotherapy, radiation therapy and intrathecal methotrexate. Two cases had primary cerebral lymphoma, although without associated immunodeficiency Twenty patients (2%) had intracranial hemorrhage, in clear relationship with platelet alterations. Fifteen patients (1.5%) had CNS infection, caused by common bacteriae or opportunistic agents. In 7 cases, the diagnosis was made at autopsy. Thirty-six autopsies were performed. In 8 cases (22%), pathologic findings such as, demyelination, microcalcificat ons, coagulative necrosis, or gliosis, suggested complications from treatment. |
| first_indexed | 2024-04-12T11:01:40Z |
| format | Article |
| id | doaj.art-c9b8d2c14786449d9b74e166ac2b30fa |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-04-12T11:01:40Z |
| publishDate | 1990-09-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-c9b8d2c14786449d9b74e166ac2b30fa2022-12-22T03:35:57ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42271990-09-0148330631410.1590/S0004-282X1990000300007S0004-282X1990000300007Craniocerebral involvement in lymphomaJorge D. Correale0David A. Monteverde1José A. Bueri2Edgardo G. Reich3Néstor Lucatelli4Hospital General de Agudos J. M. Ramos MejíaHospital General de Agudos J. M. Ramos MejíaHospital General de Agudos J. M. Ramos MejíaHospital General de Agudos J. M. Ramos MejíaHospital General de Agudos J. M. Ramos MejíaNine-hundred-eighty-nine patients with lymphoma were studied. Fifty-three cases (5.3%) had lymphomatous craniocerebral infiltration. The principal factors of risk for this complication were: advanced stage of the lymphoma (III or IV), diffuse histiocytic, diffuse poorly differentiated lymphocytic, or mixed cellularity lymphoma histological type, bone marrow involvement, and previous systemic chemotherapy. Thirty-two per cent of the cases of meningeal lymphomatous infiltration were asymptomatic and represented autopsy findings. CT-scan was an useful test to detect brain focal parenchymatous infiltration, as opposed to meningeal infiltration. Mean survival time in patients with lymphomatous meningeal infiltration was 4.3 months, following the combined use of systemic chemotherapy, radiation therapy and intrathecal methotrexate. Two cases had primary cerebral lymphoma, although without associated immunodeficiency Twenty patients (2%) had intracranial hemorrhage, in clear relationship with platelet alterations. Fifteen patients (1.5%) had CNS infection, caused by common bacteriae or opportunistic agents. In 7 cases, the diagnosis was made at autopsy. Thirty-six autopsies were performed. In 8 cases (22%), pathologic findings such as, demyelination, microcalcificat ons, coagulative necrosis, or gliosis, suggested complications from treatment.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1990000300007&lng=en&tlng=en |
| spellingShingle | Jorge D. Correale David A. Monteverde José A. Bueri Edgardo G. Reich Néstor Lucatelli Craniocerebral involvement in lymphoma Arquivos de Neuro-Psiquiatria |
| title | Craniocerebral involvement in lymphoma |
| title_full | Craniocerebral involvement in lymphoma |
| title_fullStr | Craniocerebral involvement in lymphoma |
| title_full_unstemmed | Craniocerebral involvement in lymphoma |
| title_short | Craniocerebral involvement in lymphoma |
| title_sort | craniocerebral involvement in lymphoma |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1990000300007&lng=en&tlng=en |
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