Post-infectious inflammatory response syndrome in an HIV-negative patient after Cryptococcus gattii meningoencephalitis: a case report and review of the literature
Abstract Background Cryptococcal meningitis (CM) is an inflammatory mycosis of the central nervous system caused by meninge infection or brain parenchyma with Cryptococcus species. It is associated with high morbidity and mortality, and patients with acquired immune deficiency syndrome are particula...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | https://doi.org/10.1186/s13256-023-04066-x |
| _version_ | 1797752722283298816 |
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| author | Jianhua Lan Luyi Lv Ling Ye Tao Wang Zhiyu Wu Shugen Wu Chunxian Peng Weili Lu Tao Lu |
| author_facet | Jianhua Lan Luyi Lv Ling Ye Tao Wang Zhiyu Wu Shugen Wu Chunxian Peng Weili Lu Tao Lu |
| author_sort | Jianhua Lan |
| collection | DOAJ |
| description | Abstract Background Cryptococcal meningitis (CM) is an inflammatory mycosis of the central nervous system caused by meninge infection or brain parenchyma with Cryptococcus species. It is associated with high morbidity and mortality, and patients with acquired immune deficiency syndrome are particularly susceptible. There have been increasing reports of CM in HIV-negative patients in China over the last few years. Case presentation A 31-year-old healthy Chinese male presented with fever and gradually developed headache, projectile vomiting, and other manifestations that were later confirmed as Cryptococcus gattii meningoencephalitis. However, multiple disease changes occurred during the course of treatment, and the regimen was accordingly modified after the diagnosis of post-infectious inflammatory response syndrome (PIIRS). The patient eventually recovered. Conclusion There has been a growing trend in the incidence of C. gattii meningoencephalitis in HIV-negative patients. It shows rapid onset and severe prognosis. This case report can provide a reference to treat PIIRS following CM in HIV-negative patients. |
| first_indexed | 2024-03-12T17:08:37Z |
| format | Article |
| id | doaj.art-c9b918aa052546fe8cff94c75e7e71f3 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-03-12T17:08:37Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-c9b918aa052546fe8cff94c75e7e71f32023-08-06T11:15:38ZengBMCJournal of Medical Case Reports1752-19472023-08-011711610.1186/s13256-023-04066-xPost-infectious inflammatory response syndrome in an HIV-negative patient after Cryptococcus gattii meningoencephalitis: a case report and review of the literatureJianhua Lan0Luyi Lv1Ling Ye2Tao Wang3Zhiyu Wu4Shugen Wu5Chunxian Peng6Weili Lu7Tao Lu8The 2nd Clinical Medical College of Zhejiang Chinese Medical UniversityThe 2nd Clinical Medical College of Zhejiang Chinese Medical UniversityThe 2nd Clinical Medical College of Zhejiang Chinese Medical UniversityDepartment of Infectious Diseases, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s HospitalDepartment of Infectious Diseases, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s HospitalDepartment of Infectious Diseases, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s HospitalDepartment of Infectious Diseases, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s HospitalDepartment of Infectious Diseases, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s HospitalDepartment of Infectious Diseases, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s HospitalAbstract Background Cryptococcal meningitis (CM) is an inflammatory mycosis of the central nervous system caused by meninge infection or brain parenchyma with Cryptococcus species. It is associated with high morbidity and mortality, and patients with acquired immune deficiency syndrome are particularly susceptible. There have been increasing reports of CM in HIV-negative patients in China over the last few years. Case presentation A 31-year-old healthy Chinese male presented with fever and gradually developed headache, projectile vomiting, and other manifestations that were later confirmed as Cryptococcus gattii meningoencephalitis. However, multiple disease changes occurred during the course of treatment, and the regimen was accordingly modified after the diagnosis of post-infectious inflammatory response syndrome (PIIRS). The patient eventually recovered. Conclusion There has been a growing trend in the incidence of C. gattii meningoencephalitis in HIV-negative patients. It shows rapid onset and severe prognosis. This case report can provide a reference to treat PIIRS following CM in HIV-negative patients.https://doi.org/10.1186/s13256-023-04066-xMycosisCryptococcus gattiiInflammatory response syndromeMeningoencephalitis |
| spellingShingle | Jianhua Lan Luyi Lv Ling Ye Tao Wang Zhiyu Wu Shugen Wu Chunxian Peng Weili Lu Tao Lu Post-infectious inflammatory response syndrome in an HIV-negative patient after Cryptococcus gattii meningoencephalitis: a case report and review of the literature Journal of Medical Case Reports Mycosis Cryptococcus gattii Inflammatory response syndrome Meningoencephalitis |
| title | Post-infectious inflammatory response syndrome in an HIV-negative patient after Cryptococcus gattii meningoencephalitis: a case report and review of the literature |
| title_full | Post-infectious inflammatory response syndrome in an HIV-negative patient after Cryptococcus gattii meningoencephalitis: a case report and review of the literature |
| title_fullStr | Post-infectious inflammatory response syndrome in an HIV-negative patient after Cryptococcus gattii meningoencephalitis: a case report and review of the literature |
| title_full_unstemmed | Post-infectious inflammatory response syndrome in an HIV-negative patient after Cryptococcus gattii meningoencephalitis: a case report and review of the literature |
| title_short | Post-infectious inflammatory response syndrome in an HIV-negative patient after Cryptococcus gattii meningoencephalitis: a case report and review of the literature |
| title_sort | post infectious inflammatory response syndrome in an hiv negative patient after cryptococcus gattii meningoencephalitis a case report and review of the literature |
| topic | Mycosis Cryptococcus gattii Inflammatory response syndrome Meningoencephalitis |
| url | https://doi.org/10.1186/s13256-023-04066-x |
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