The Inflammatory Response After Ischemic Stroke: Targeting β2 and β1 Integrins
Ischemic stroke is a leading cause of death and disability with limited therapeutic options. Resulting inflammatory mechanisms after reperfusion (removal of the thrombus) result in cytokine activation, calcium influx, and leukocytic infiltration to the area of ischemia. In particular, leukocytes mig...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-05-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.00540/full |
| _version_ | 1811298508706152448 |
|---|---|
| author | Danielle N. Edwards Danielle N. Edwards Gregory J. Bix Gregory J. Bix |
| author_facet | Danielle N. Edwards Danielle N. Edwards Gregory J. Bix Gregory J. Bix |
| author_sort | Danielle N. Edwards |
| collection | DOAJ |
| description | Ischemic stroke is a leading cause of death and disability with limited therapeutic options. Resulting inflammatory mechanisms after reperfusion (removal of the thrombus) result in cytokine activation, calcium influx, and leukocytic infiltration to the area of ischemia. In particular, leukocytes migrate toward areas of inflammation by use of integrins, particularly integrins β1 and β2. Integrins have been shown to be necessary for leukocyte adhesion and migration, and thus are of immediate interest in many inflammatory diseases, including ischemic stroke. In this review, we identify the main integrins involved in leukocytic migration following stroke (αLβ2, αDβ2, α4β1, and α5β1) and targeted clinical therapeutic interventions. |
| first_indexed | 2024-04-13T06:20:20Z |
| format | Article |
| id | doaj.art-c9b9e2759ed74c8a9ca9e538686dadf0 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-13T06:20:20Z |
| publishDate | 2019-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-c9b9e2759ed74c8a9ca9e538686dadf02022-12-22T02:58:41ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-05-011310.3389/fnins.2019.00540458890The Inflammatory Response After Ischemic Stroke: Targeting β2 and β1 IntegrinsDanielle N. Edwards0Danielle N. Edwards1Gregory J. Bix2Gregory J. Bix3Sanders–Brown Center on Aging, University of Kentucky, Lexington, KY, United StatesDepartment of Neuroscience, University of Kentucky, Lexington, KY, United StatesDepartment of Neurology, University of Kentucky, Lexington, KY, United StatesDepartment of Neurosurgery, University of Kentucky, Lexington, KY, United StatesIschemic stroke is a leading cause of death and disability with limited therapeutic options. Resulting inflammatory mechanisms after reperfusion (removal of the thrombus) result in cytokine activation, calcium influx, and leukocytic infiltration to the area of ischemia. In particular, leukocytes migrate toward areas of inflammation by use of integrins, particularly integrins β1 and β2. Integrins have been shown to be necessary for leukocyte adhesion and migration, and thus are of immediate interest in many inflammatory diseases, including ischemic stroke. In this review, we identify the main integrins involved in leukocytic migration following stroke (αLβ2, αDβ2, α4β1, and α5β1) and targeted clinical therapeutic interventions.https://www.frontiersin.org/article/10.3389/fnins.2019.00540/fullischemic strokeintegrinsinflammationleukocytesclinical trial results |
| spellingShingle | Danielle N. Edwards Danielle N. Edwards Gregory J. Bix Gregory J. Bix The Inflammatory Response After Ischemic Stroke: Targeting β2 and β1 Integrins Frontiers in Neuroscience ischemic stroke integrins inflammation leukocytes clinical trial results |
| title | The Inflammatory Response After Ischemic Stroke: Targeting β2 and β1 Integrins |
| title_full | The Inflammatory Response After Ischemic Stroke: Targeting β2 and β1 Integrins |
| title_fullStr | The Inflammatory Response After Ischemic Stroke: Targeting β2 and β1 Integrins |
| title_full_unstemmed | The Inflammatory Response After Ischemic Stroke: Targeting β2 and β1 Integrins |
| title_short | The Inflammatory Response After Ischemic Stroke: Targeting β2 and β1 Integrins |
| title_sort | inflammatory response after ischemic stroke targeting β2 and β1 integrins |
| topic | ischemic stroke integrins inflammation leukocytes clinical trial results |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.00540/full |
| work_keys_str_mv | AT daniellenedwards theinflammatoryresponseafterischemicstroketargetingb2andb1integrins AT daniellenedwards theinflammatoryresponseafterischemicstroketargetingb2andb1integrins AT gregoryjbix theinflammatoryresponseafterischemicstroketargetingb2andb1integrins AT gregoryjbix theinflammatoryresponseafterischemicstroketargetingb2andb1integrins AT daniellenedwards inflammatoryresponseafterischemicstroketargetingb2andb1integrins AT daniellenedwards inflammatoryresponseafterischemicstroketargetingb2andb1integrins AT gregoryjbix inflammatoryresponseafterischemicstroketargetingb2andb1integrins AT gregoryjbix inflammatoryresponseafterischemicstroketargetingb2andb1integrins |