Effects of Flavonoids in Lysimachia clethroides Duby on the Activities of Cytochrome P450 CYP2E1 and CYP3A4 in Rat Liver Microsomes

Effects of Flavonoids in Lysimachia clethroides Duby on the Activities of Cytochrome P450 CYP2E1 and CYP3A4 in Rat Liver Microsomes

Incubation systems were established to investigate the effects of quercetin, kaempferol, isoquercitrin and astragalin in Lysimachia clethroides Duby on the activities of CYP2E1 and CYP3A4 in rat liver microsomes in vitro. Probe substrates of 4-nitrophenol and testosterone as well as flavonoids at di...

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Bibliographic Details
Main Authors: Zhi-Juan Zhang, Zhao-Yang Xia, Jin-Mei Wang, Xue-Ting Song, Jin-Feng Wei, Wen-Yi Kang
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:Molecules
Subjects:
Lysimachia clethroides Duby
flavonoids
HPLC
CYP2E1
CYP3A4
liver microsomes
Online Access:http://www.mdpi.com/1420-3049/21/6/738

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