Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications
Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide. Despite advances in the treatment management, locally advanced disease has a poor prognosis, with a 5-year survival rate of approximately 50%. The growth of HNSCC is maintained by a population of can...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/11/5/616 |
| _version_ | 1797723648330563584 |
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| author | Claudia Peitzsch Jacqueline Nathansen Sebastian I. Schniewind Franziska Schwarz Anna Dubrovska |
| author_facet | Claudia Peitzsch Jacqueline Nathansen Sebastian I. Schniewind Franziska Schwarz Anna Dubrovska |
| author_sort | Claudia Peitzsch |
| collection | DOAJ |
| description | Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide. Despite advances in the treatment management, locally advanced disease has a poor prognosis, with a 5-year survival rate of approximately 50%. The growth of HNSCC is maintained by a population of cancer stem cells (CSCs) which possess unlimited self-renewal potential and induce tumor regrowth if not completely eliminated by therapy. The population of CSCs is not only a promising target for tumor treatment, but also an important biomarker to identify the patients at risk for therapeutic failure and disease progression. This review aims to provide an overview of the recent pre-clinical and clinical studies on the biology and potential therapeutic implications of HNSCC stem cells. |
| first_indexed | 2024-03-12T10:05:46Z |
| format | Article |
| id | doaj.art-c9c37732c67544c3918f1d9991f9aa25 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T10:05:46Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-c9c37732c67544c3918f1d9991f9aa252023-09-02T11:19:15ZengMDPI AGCancers2072-66942019-05-0111561610.3390/cancers11050616cancers11050616Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical ImplicationsClaudia Peitzsch0Jacqueline Nathansen1Sebastian I. Schniewind2Franziska Schwarz3Anna Dubrovska4National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; and Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01307 Dresden, GermanyOncoRay—National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, GermanyOncoRay—National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, GermanyOncoRay—National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, GermanyOncoRay—National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, GermanyHead and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide. Despite advances in the treatment management, locally advanced disease has a poor prognosis, with a 5-year survival rate of approximately 50%. The growth of HNSCC is maintained by a population of cancer stem cells (CSCs) which possess unlimited self-renewal potential and induce tumor regrowth if not completely eliminated by therapy. The population of CSCs is not only a promising target for tumor treatment, but also an important biomarker to identify the patients at risk for therapeutic failure and disease progression. This review aims to provide an overview of the recent pre-clinical and clinical studies on the biology and potential therapeutic implications of HNSCC stem cells.https://www.mdpi.com/2072-6694/11/5/616head and neck squamous cell carcinomaHNSCCcancer stem cellstherapy resistancebiomarkers |
| spellingShingle | Claudia Peitzsch Jacqueline Nathansen Sebastian I. Schniewind Franziska Schwarz Anna Dubrovska Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications Cancers head and neck squamous cell carcinoma HNSCC cancer stem cells therapy resistance biomarkers |
| title | Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications |
| title_full | Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications |
| title_fullStr | Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications |
| title_full_unstemmed | Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications |
| title_short | Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications |
| title_sort | cancer stem cells in head and neck squamous cell carcinoma identification characterization and clinical implications |
| topic | head and neck squamous cell carcinoma HNSCC cancer stem cells therapy resistance biomarkers |
| url | https://www.mdpi.com/2072-6694/11/5/616 |
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